Principal component analysis of FDG PET in amnestic MCI

被引:73
作者
Nobili, Flavio [1 ,2 ,3 ]
Salmaso, Dario [4 ,5 ]
Morbelli, Silvia [6 ]
Girtler, Nicola [1 ,2 ,3 ]
Piccardo, Arnoldo [7 ]
Brugnolo, Andrea [1 ,2 ,3 ]
Dessi, Barbara [1 ,2 ,3 ]
Larsson, Stig A. [8 ]
Rodriguez, Guido [1 ,2 ,3 ]
Pagani, Marco [4 ,5 ,8 ]
机构
[1] Univ Genoa, Dept Endocrinol & Med Sci, I-16132 Genoa, Italy
[2] San Martino Hosp, Alzheimer Evaluat Unit, Genoa, Italy
[3] San Martino Hosp, Head Neck Dept, Genoa, Italy
[4] CNR, Inst Cognit Sci & Technol, Rome, Italy
[5] CNR, Inst Cognit Sci & Technol, Padua, Italy
[6] Univ Genoa, Dept Internal Med, Nucl Med Unit, I-16126 Genoa, Italy
[7] Galliera Hosp, Dept Diagnost Imaging, Nucl Med Unit, Genoa, Italy
[8] Karolinska Hosp, Dept Nucl Med, S-10401 Stockholm, Sweden
关键词
F-18-FDG PET; Episodic memory; Mild cognitive impairment; Alzheimer's disease;
D O I
10.1007/s00259-008-0869-z
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose The purpose of the study is to evaluate the combined accuracy of episodic memory performance and F-18-FDG PET in identifying patients with amnestic mild cognitive impairment (aMCI) converting to Alzheimer's disease (AD), aMCI non-converters, and controls. Methods Thirty-three patients with aMCI and 15 controls (CTR) were followed up for a mean of 21 months. Eleven patients developed AD (MCI/AD) and 22 remained with aMCI (MCI/MCI). F-18-FDG PET volumetric regions of interest underwent principal component analysis (PCA) that identified 12 principal components (PC), expressed by coarse component scores (CCS). Discriminant analysis was performed using the significant PCs and episodic memory scores. Results PCA highlighted relative hypometabolism in PC5, including bilateral posterior cingulate and left temporal pole, and in PC7, including the bilateral orbitofrontal cortex, both in MCI/MCI and MCI/AD vs CTR. PC5 itself plus PC12, including the left lateral frontal cortex (LFC: BAs 44, 45, 46, 47), were significantly different between MCI/AD and MCI/MCI. By a three-group discriminant analysis, CTR were more accurately identified by PET-CCS + delayed recall score (100%), MCI/MCI by PET-CCS + either immediate or delayed recall scores (91%), while MCI/AD was identified by PET-CCS alone (82%). PET increased by 25% the correct allocations achieved by memory scores, while memory scores increased by 15% the correct allocations achieved by PET. Conclusion Combining memory performance and F-18-FDG PET yielded a higher accuracy than each single tool in identifying CTR and MCI/MCI. The PC containing bilateral posterior cingulate and left temporal pole was the hallmark of MCI/MCI patients, while the PC including the left LFC was the hallmark of conversion to AD.
引用
收藏
页码:2191 / 2202
页数:12
相关论文
共 61 条
[1]   Variability of trail making test, symbol digit test and line trait test in normal people. A normative study taking into account age-dependent decline and sociobiological variables [J].
Amodio, P ;
Wenin, H ;
Del Piccolo, F ;
Mapelli, D ;
Montagnese, S ;
Pellegrini, A ;
Musto, C ;
Gatta, A ;
Umilta, C .
AGING CLINICAL AND EXPERIMENTAL RESEARCH, 2002, 14 (02) :117-131
[2]   Heterogeneity of brain glucose metabolism in mild cognitive impairment and clinical progression to Alzheimer disease [J].
Anchisi, D ;
Borroni, B ;
Franceschi, M ;
Kerrouche, N ;
Kalbe, E ;
Beuthien-Beumann, B ;
Cappa, S ;
Lenz, O ;
Ludecke, S ;
Marcone, A ;
Mielke, R ;
Ortelli, P ;
Padovani, A ;
Pelati, O ;
Pupi, A ;
Scarpini, E ;
Weisenbach, S ;
Herholz, K ;
Salmon, E ;
Holthoff, V ;
Sorbi, S ;
Fazio, F ;
Perani, D .
ARCHIVES OF NEUROLOGY, 2005, 62 (11) :1728-1733
[3]   Implementation and validation of a fully automatic system for intra- and interindividual registration of PET brain scans [J].
Andersson, JLR ;
Thurfjell, L .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1997, 21 (01) :136-144
[4]  
[Anonymous], 1987, ITAL J NEUROL SCI
[5]   A normative study on visual reaction times and two Stroop colour-word tests [J].
Barbarotto, R ;
Laiacona, M ;
Frosio, R ;
Vecchio, M ;
Farinato, A ;
Capitani, E .
ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1998, 19 (03) :161-170
[6]  
Bartenstein P, 2002, EUR J NUCL MED MOL I, V29, pBP43
[7]   Heterogeneous age-related breakdown of white matter structural integrity: implications for cortical "disconnection" in aging and Alzheimer's diesase [J].
Bartzokis, G ;
Sultzer, D ;
Lu, PH ;
Neuchterlein, KH ;
Mintz, J ;
Cummings, JL .
NEUROBIOLOGY OF AGING, 2004, 25 (07) :843-851
[8]   Natural history of mild cognitive impairment in older persons [J].
Bennett, DA ;
Wilson, RS ;
Schneider, JA ;
Evans, DA ;
Beckett, LA ;
Aggarwal, NT ;
Barnes, LL ;
Fox, JH ;
Bach, J .
NEUROLOGY, 2002, 59 (02) :198-205
[9]   Alzheimer's disease [J].
Blennow, Kaj ;
de Leon, Mony J. ;
Zetterberg, Henrik .
LANCET, 2006, 368 (9533) :387-403
[10]   Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis [J].
Braak, H ;
Braak, E .
ACTA NEUROPATHOLOGICA, 1996, 92 (02) :197-201