Contribution of the glycoprotein Ia 807TT, methylene tetrahydrofolate reductase 677TT and prothrombin 20210GA genotypes to prothrombotic risk among factor V 1691GA (Leiden) carriers

被引：15

作者：

Hessner, MJ ^{[1
]}

Dinauer, DM ^{[1
]}

Luhm, RA ^{[1
]}

Endres, JL ^{[1
]}

Montgomery, RR ^{[1
]}

Friedman, KD ^{[1
]}

机构：

[1] Blood Ctr SE Wisconsin Inc, Diagnost Labs, Milwaukee, WI 53201 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1999年 / 106卷 / 01期

关键词：

venous thrombosis; prothrombin; methylene tetrahydrofolate reductase; factor V Leiden; glycoprotein Ia;

D O I：

10.1046/j.1365-2141.1999.01514.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The cooperative effects of the GPIa 807TT, MTHFR 677TT and prothrombin 20210GA genotypes with the FV Leiden 1691GA (FVL) genotype were evaluated by comparing these genotype frequencies in 77 asymptomatic and 156 symptomatic heterozygous FVL carriers. The GPIa 807TT and MTHFR 677TT genotypes did not segregate within the symptomatic FVL carrier group and did not contribute to venous thrombotic risk in this patient cohort. There was no difference in the prothrombin 20210GA genotype frequency between asymptomatic FVL carriers and a random Caucasian control group; however, the prothrombin 20210GA genotype was nearly 5 times as prevalent (19/156 v 2/77; P < 0.02) in the symptomatic FVL carriers (odds ratio 5.21: 95% confidence interval 1.20-47.62), demonstrating that this important prothrombotic risk factor acts synergistically with FVL.

引用

页码：237 / 239

页数：3

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