Long-term caloric restriction ameliorates the decline in diastolic function in humans

被引:285
作者
Meyer, TE
Kovács, SJ
Ehsani, AA
Klein, S
Holloszy, JO
Fontana, L
机构
[1] Washington Univ, Sch Med, Div Geriatr & Nutr Sci, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Cardiovasc Biophys Lab, St Louis, MO 63110 USA
[3] Ist Super Sanita, Div Human Nutr, I-00161 Rome, Italy
关键词
D O I
10.1016/j.jacc.2005.08.069
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVES We determined whether caloric restriction (CR) has cardiac-specific effects that attenuate the established aging-associated impairments in diastolic function (DF). BACKGROUND Caloric restriction retards the aging process in small mammals; however, no information is available on the effects of long-term CR on human aging. In healthy individuals, Doppler echocardiography has established the pattern of aging-associated DF impairment, whereas little change is observed in systolic function (SF). METHODS Diastolic function was assessed in 25 subjects (age 53 +/- 12 years) practicing CR for 6.5 +/- 4.6 years and 25 age- and gender-matched control subjects consuming Western diets. Diastolic function was quantified by transmittal flow, Doppler tissue imaging, and model-based image processing (MBIP) of E waves. C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and transforming growth factor-beta(1) (TGF-beta(1)) were also measured. RESULTS No difference in SF was observed between groups; however, standard transmittal Doppler flow DF indexes of the CR group were similar to those of younger individuals, and MBIP-based, flow-derived DF indexes, reflecting chamber viscoelasticity and stiffness, were significantly lower than in control subjects. Blood pressure, serum CRP, TNF-a, and TGF-beta(1) levels were significantly lower in the CR group (102 +/- 10/61 +/- 7 mm Hg, 0.3 +/- 0.3 mg/l, 0.8 +/- 0.5 pg/ml, 29.4 +/- 6.9 ng/ml, respectively) compared with the Western diet group (131 +/- 11/83 +/- 6 mm Hg, 1.9 +/- 2.8 mg/l, 1.5 +/- 1.0 pg/ml, 35.4 +/- 7.1 ng/ml, respectively). CONCLUSIONS Caloric restriction has cardiac-specific effects that ameliorate aging-associated changes in DF. These beneficial effects on cardiac function might be mediated by the effect of CR on blood pressure, systemic inflammation, and myocardial fibrosis.
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页码:398 / 402
页数:5
相关论文
共 18 条
[1]  
APPLETON CP, 2000, DIASTOLIC FUNCTION D, P513
[2]  
BORDER WA, 1992, J CLIN INVEST, V85, P507
[3]   Myocardial fibrosis in transforming growth factor β1 heterozygous mice [J].
Brooks, WW ;
Conrad, CH .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2000, 32 (02) :187-195
[4]   Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans [J].
Fontana, L ;
Meyer, TE ;
Klein, S ;
Holloszy, JO .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (17) :6659-6663
[5]   AUTOMATED-METHOD FOR CHARACTERIZATION OF DIASTOLIC TRANSMITRAL DOPPLER VELOCITY CONTOURS - EARLY RAPID FILLING [J].
HALL, AF ;
KOVACS, SJ .
ULTRASOUND IN MEDICINE AND BIOLOGY, 1994, 20 (02) :107-116
[6]   AGE-RELATED ALTERATIONS OF DOPPLER LEFT-VENTRICULAR FILLING INDEXES IN NORMAL SUBJECTS ARE INDEPENDENT OF LEFT-VENTRICULAR MASS, HEART-RATE, CONTRACTILITY AND LOADING CONDITIONS [J].
KITZMAN, DW ;
SHEIKH, KH ;
BEERE, PA ;
PHILIPS, JL ;
HIGGINBOTHAM, MB .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1991, 18 (05) :1243-1250
[7]   EVALUATION OF DIASTOLIC FUNCTION WITH DOPPLER ECHOCARDIOGRAPHY - THE PDF FORMALISM [J].
KOVACS, SJ ;
BARZILAI, B ;
PEREZ, JE .
AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 252 (01) :H178-H187
[8]   Varying body mass index cutoff points to describe overweight prevalence among US Adults: NHANES III (1988 to 1994) [J].
Kuczmarski, RJ ;
Carroll, MD ;
Flegal, KM ;
Troiano, RP .
OBESITY RESEARCH, 1997, 5 (06) :542-548
[9]   Chamber properties from transmitral flow: prediction of average and passive left ventricular diastolic stiffness [J].
Lisauskas, JB ;
Singh, J ;
Bowman, AW ;
Kovacs, SJ .
JOURNAL OF APPLIED PHYSIOLOGY, 2001, 91 (01) :154-162
[10]   LEFT-VENTRICULAR DIASTOLIC FILLING AND ITS ASSOCIATION WITH AGE [J].
MILLER, TR ;
GROSSMAN, SJ ;
SCHECTMAN, KB ;
BIELLO, DR ;
LUDBROOK, PA ;
EHSANI, AA .
AMERICAN JOURNAL OF CARDIOLOGY, 1986, 58 (06) :531-535