Prospective study of moderate alcohol consumption and risk of peripheral arterial disease in US male physicians

被引：87

作者：

Camargo, CA

Stampfer, MJ

Glynn, RJ

Gaziano, JM

Manson, JE

Goldhaber, SZ

Hennekens, CH

机构：

[1] CHANNING LABS, DIV PREVENT MED, BOSTON, MA USA

[2] CHANNING LABS, DIV CARDIOL, BOSTON, MA USA

[3] HARVARD UNIV, MASSACHUSETTS GEN HOSP, SCH MED, DEPT EMERGENCY MED, CAMBRIDGE, MA 02138 USA

[4] HARVARD UNIV, SCH MED, DEPT AMBULATORY CARE & PREVENT, CAMBRIDGE, MA 02138 USA

[5] HARVARD UNIV, SCH PUBL HLTH, DEPT EPIDEMIOL, BOSTON, MA 02115 USA

[6] HARVARD UNIV, SCH PUBL HLTH, DEPT BIOSTAT, BOSTON, MA 02115 USA

[7] HARVARD UNIV, SCH PUBL HLTH, DEPT NUTR, BOSTON, MA 02115 USA

来源：

CIRCULATION | 1997年 / 95卷 / 03期

关键词：

alcohol; claudication; follow-up studies; peripheral vascular disease;

D O I：

10.1161/01.CIR.95.3.577

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Moderate alcohol consumption decreases the risk of coronary heart d Methods and Results In the Physicians' Health Study, a randomized trial of the use of aspirin and beta-carotene in 22 071 apparently healthy men, we documented 433 incident cases of PAD during 11 years of follow-up. After we controlled for age and treatment assignment, daily drinkers (greater than or equal to 7 drinks per week) had a relative risk (RR) of PAD of 0.92 (95% confidence interval, 0.72 to 1.17) compared with the reference group (< 1 drink per week). After additional control for smoking, however, the RR was 0.68 (0.52 to 0.89). Further control for exercise, diabetes mellitus, and parental history of myocardial infarction revealed an RR of 0.74 (0.57 to 0.97). Conclusions Moderate alcohol consumption appears to decrease the risk of PAD in apparently healthy men.

引用

页码：577 / 580

页数：4

共 35 条

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