The shape of things to come: An emerging role for protein kinase CK2 in the regulation of cell morphology and the cytoskeleton

被引：92

作者：

Canton, DA ^{[1
]}

Litchfield, DW ^{[1
]}

机构：

[1] Univ Western Ontario, Regulatory Biol & Funct Genom Grp, Siebens Drake Med Res Inst, Dept Biochem,Schulich Sch Med & Dent, London, ON N6A 5C1, Canada

来源：

CELLULAR SIGNALLING | 2006年 / 18卷 / 03期

基金：

加拿大健康研究院;

关键词：

protein kinase CK2; protein kinase; cytoskeleton; morphology; cell polarity;

D O I：

10.1016/j.cellsig.2005.07.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Protein kinase CK2 is a highly conserved, pleiotropic, protein serine/threonine kinase that is essential for life in eukaryotes. CK2 has been implicated in diverse cellular processes such as cell cycle regulation, circadian rhythms, apoptosis, transformation and tumorigenesis. In addition, there is increasing evidence that CK2 is involved in the maintenance of cell morphology and cell polarity, and in the regulation of the actin and tubulin cytoskeletons. Accordingly, this review will highlight published evidence in experimental models ranging from yeast to mammals documenting the emerging roles of protein kinase CK2 in the regulation of cell polarity, cell morphology and the cytoskeleton. (c) 2005 Elsevier Inc. All rights reserved.

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页码：267 / 275

页数：9

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