Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors

被引：965

作者：

Arase, H

Mocarski, ES

Campbell, AE

Hill, AB

Lanier, LL ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Canc Res Inst, San Francisco, CA 94143 USA

[3] Stanford Univ, Dept Microbiol & Immunol, Stanford, CA 94305 USA

[4] Eastern Virginia Med Sch, Dept Microbiol & Mol Cell Biol, Norfolk, VA 23507 USA

[5] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, Portland, OR 97201 USA

来源：

SCIENCE | 2002年 / 296卷 / 5571期

关键词：

D O I：

10.1126/science.1070884

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Natural killer (NK) cells express inhibitory receptors for major histocompatibility complex (MHC) class I antigens, preventing attack against healthy cells. Mouse cytomegatovirus (MCMV) encodes an MHC-like protein (m157) that binds to an inhibitory NK cell receptor in certain MCMV-susceptible mice. In MCMV-resistant mice, this viral protein engages a related activating receptor (Ly49H) and confers host protection. These activating and inhibitory receptors are highly homologous, suggesting the possibility that one evolved from the other in response to selective pressure imposed by the pathogen.

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收藏

页码：1323 / 1326

页数：4

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