Exploring the full spectrum of macrophage activation

被引：7156

作者：

Mosser, David M. ^{[1
]}

Edwards, Justin P.

机构：

[1] Univ Maryland, Dept Mol Genet & Cell Biol, College Pk, MD 20742 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri2448

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Macrophages display remarkable plasticity and can change their physiology in response to environmental cues. These changes can give rise to different populations of cells with distinct functions. In this Review we suggest a new grouping of macrophage populations based on three different homeostatic activities-host defence, wound healing and immune regulation. We propose that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation. We characterize each population and provide examples of macrophages from specific disease states that have the characteristics of one or more of these populations.

引用

页码：958 / 969

页数：12

共 119 条

[1] Anthrax lethal toxin: a weapon of multisystem destruction [J].

Agrawal, A ;

Pulendran, B .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2004, 61 (22) :2859-2865

[2] Local self-renewal can sustain CNS microglia maintenance and function throughout adult life [J].

Ajami, Bahareh ;

Bennett, Jami L. ;

Krieger, Charles ;

Tetzlaff, Wolfram ;

Rossi, Fabio M. V. .

NATURE NEUROSCIENCE, 2007, 10 (12) :1538-1543

[3] Siglec-9 enhances IL-10 production in macrophages via tyrosine-based motifs [J].

Ando, Munetoshi ;

Tu, Wenjie ;

Nishijima, Ken-Ichi ;

Iijima, Shinji .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 369 (03) :878-883

[4] Memory TH2 cells induce alternatively activated macrophages to mediate protection against nematode parasites [J].

Anthony, Robert M. ;

Urban, Joseph F., Jr. ;

Alem, Farhang ;

Hamed, Hossein A. ;

Rozo, Cristina T. ;

Boucher, Jean-Luc ;

Van Rooijen, Nico ;

Gause, William C. .

NATURE MEDICINE, 2006, 12 (08) :955-960

[5] Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior [J].

Auffray, Cedric ;

Fogg, Darin ;

Garfa, Meriem ;

Elain, Gaelle ;

Join-Lambert, Olivier ;

Kayal, Samer ;

Sarnacki, Sabine ;

Cumano, Ana ;

Lauvau, Gregoire ;

Geissmann, Frederic .

SCIENCE, 2007, 317 (5838) :666-670

[6]

Bastard JP, 2006, EUR CYTOKINE NETW, V17, P4

[7] Coxiella burnetti, the agent of Q fever, stimulates an atypical M2 activation program in human macrophages [J].

Benoit, Marie ;

Barbarat, Bernadette ;

Bernard, Alain ;

Olive, Daniel ;

Mege, Jean-Louis .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2008, 38 (04) :1065-1070

[8]

Betti M, 2006, ANN ONCOL, V17, P235

[9] A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-κB and enhanced IRF-3/STAT1 activation) [J].

Biswas, SK ;

Gangi, L ;

Paul, S ;

Schioppa, T ;

Saccani, A ;

Sironi, M ;

Bottazzi, B ;

Doni, A ;

Vincenzo, B ;

Pasqualini, F ;

Vago, L ;

Nebuloni, M ;

Mantovani, A ;

Sica, A .

BLOOD, 2006, 107 (05) :2112-2122

[10]

Bleau G, 1999, EXS, V87, P211

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