Statin therapy and autoimmune disease: from protein prenylation to immunomodulation

被引：555

作者：

Greenwood, J

Steinman, L

Zamvil, SS

机构：

[1] UCL, Dept Cell Biol, Inst Ophthalmol, London EC1V 9EL, England

[2] Stanford Univ, Dept Neurol & Neurol Sci, Beckman Ctr Mol Med, Stanford, CA 94305 USA

[3] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 05期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nri1839

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Statins have been prescribed extensively for their cholesterol-lowering properties and efficacy in cardiovascular disease. However, compelling evidence now exists that statins also have extensive immunomodulatory properties that operate independently of lipid lowering. Consequently, much attention has been directed towards their potential as therapeutic agents for the treatment of autoimmune disease. Modulation of post-translational protein prenylation seems to be a key mechanism by which statins alter immune function. In this Review, the effect of statin therapy on immune function, and how this relates to the pathogenesis of autoimmune disease, is reviewed alongside current opinion of what the key biological targets of statins are.

引用

收藏

页码：358 / 370

页数：13

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