Studies on the role of the extracellular cysteines and oligomeric structures of the P2Y12 receptor when interacting with antagonists

被引:34
作者
Ding, Z. [1 ,2 ]
Bynagari, Y. S. [1 ]
Mada, S. R. [1 ]
Jakubowski, J. A. [3 ]
Kunapuli, S. P. [1 ,2 ,4 ]
机构
[1] Temple Univ, Dept Physiol, Sch Med, Philadelphia, PA 19140 USA
[2] Temple Univ, Dept Pharmacol, Sch Med, Philadelphia, PA 19140 USA
[3] Temple Univ, Sol Sherry Thrombosis Res Ctr, Sch Med, Philadelphia, PA 19140 USA
[4] Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA
关键词
PLATELET ADP RECEPTOR; ACTIVE METABOLITE; IDENTIFICATION;
D O I
10.1111/j.1538-7836.2008.03202.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:232 / 234
页数:3
相关论文
共 12 条
[1]   Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270 [J].
Ding, ZR ;
Kim, S ;
Dorsam, RT ;
Jin, JG ;
Kunapuli, SP .
BLOOD, 2003, 101 (10) :3908-3914
[2]   Central role of the P2Y12 receptor in platelet activation [J].
Dorsam, RT ;
Kunapuli, SP .
JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (03) :340-345
[3]   Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs [J].
Foster, CJ ;
Prosser, DM ;
Agans, JM ;
Zhai, Y ;
Smith, MD ;
Lachowicz, JE ;
Zhang, FL ;
Gustafson, E ;
Monsma, FJ ;
Wiekowski, MT ;
Abbondanzo, SJ ;
Cook, DN ;
Bayne, ML ;
Lira, SA ;
Chintala, MS .
JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (12) :1591-1598
[4]   Identification of the platelet ADP receptor targeted by antithrombotic drugs [J].
Hollopeter, G ;
Jantzen, HM ;
Vincent, D ;
Li, G ;
England, L ;
Ramakrishnan, V ;
Yang, RB ;
Nurden, P ;
Nurden, A ;
Julius, D ;
Conley, PB .
NATURE, 2001, 409 (6817) :202-207
[5]   Prasugrel: A novel thienopyridine antiplatelet agent. A review of preclinical and clinical studies and the mechanistic basis for its distinct antiplatelet profile [J].
Jakubowski, Joseph A. ;
Winters, Kenneth J. ;
Naganuma, Hideo ;
Wallentin, Lars .
CARDIOVASCULAR DRUG REVIEWS, 2007, 25 (04) :357-374
[6]   Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation [J].
Jin, JG ;
Kunapuli, SP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (14) :8070-8074
[7]   Identification and biological activity of the active metabolite of clopidogrel [J].
Savi, P ;
Pereillo, JM ;
Uzabiaga, MF ;
Combalbert, J ;
Picard, C ;
Maffrand, JP ;
Pascal, M ;
Herbert, JM .
THROMBOSIS AND HAEMOSTASIS, 2000, 84 (05) :891-896
[8]   P2Y12, a new platelet ADP receptor, target of clopidogrel [J].
Savi, P ;
Labouret, C ;
Delesque, N ;
Guette, F ;
Lupker, J ;
Herbert, JM .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 283 (02) :379-383
[9]   The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts [J].
Savi, Pierre ;
Zachayus, Jean-Luc ;
Delesque-Touchard, Nathalie ;
Labouret, Catherine ;
Herve, Caroline ;
Uzabiaga, Marie-Francoise ;
Pereillo, Jean-Marie ;
Culouscou, Jean-Michel ;
Bono, Francoise ;
Ferrara, Pascual ;
Herbert, Jean-Marc .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (29) :11069-11074
[10]   Antiplatelet action of R-99224, an active metabolite of a novel thienopyridine-type Gi-linked P2T antagonist, CS-747 [J].
Sugidachi, A ;
Asai, F ;
Yoneda, K ;
Iwamura, R ;
Ogawa, T ;
Otsuguro, K ;
Koike, H .
BRITISH JOURNAL OF PHARMACOLOGY, 2001, 132 (01) :47-54