Epidermal growth factor receptor is indispensable for c-Fos expression and protein synthesis by angiotensin II

被引：39

作者：

Eguchi, S

Iwasaki, H

Hirata, Y

Frank, GD

Motley, ED

Yamakawa, T

Numaguchi, K

Inagami, T

机构：

[1] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37232 USA

[2] Tokyo Med & Dent Univ, Dept Internal Med 2, Tokyo 1138519, Japan

[3] Meharry Med Coll, Dept Anat & Physiol, Nashville, TN 37208 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1999年 / 376卷 / 1-2期

关键词：

angiotensin II; smooth muscle cell; vascular; receptor; epidermal growth factor; extracellular signal-regulated kinase; c-Fos; protein synthesis;

D O I：

10.1016/S0014-2999(99)00357-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have reported that angiotensin II induces the epidermal growth factor (EGF) receptor transactivation leading to extracellular signal-regulated kinase (ERK) activation in rat vascular smooth muscle cells. Here, we report that the EGF receptor kinase inhibitor AG1478 and the ERK kinase inhibitor PD98059 markedly inhibited angiotensin II-induced c-Fos expression and protein synthesis but not c-Jun expression in these cells. These data suggest that the EGF receptor transactivation and subsequent ERK activation are indispensable for angiotensin II-mediated growth promotion of vascular smooth muscle cells providing a new mechanistic insight whereby angiotensin II contributes abnormal vascular remodeling. (C) 1999 Elsevier Science B.V. All rights reserved.

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收藏

页码：203 / 206

页数：4

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