Hypoxia - A key regulatory factor in tumour growth

被引：4397

作者：

Harris, AL ^{[1
]}

机构：

[1] John Radcliffe Hosp, Inst Mol Med, Oxford OX3 9DS, England

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 01期

关键词：

D O I：

10.1038/nrc704

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cells undergo a variety of biological responses when placed in hypoxic conditions, including activation of signalling pathways that regulate proliferation, angiogenesis and death. Cancer cells have adapted these pathways, allowing tumours to survive and even grow under hypoxic conditions, and tumour hypoxia is associated with poor prognosis and resistance to radiation therapy. Many elements of the hypoxia-response pathway are therefore good candidates for therapeutic targeting.

引用

页码：38 / 47

页数：10

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