Stem cells and cancer: Two faces of eve

被引：679

作者：

Clarke, MF ^{[1
]}

Fuller, M

机构：

[1] Stanford Inst Stem Biol & Regenerat Med, Stanford, CA USA

[2] Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA

来源：

CELL | 2006年 / 124卷 / 06期

关键词：

D O I：

10.1016/j.cell.2006.03.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent evidence suggests that a subset of cancer cells within some tumors, the so-called cancer stem cells, may drive the growth and metastasis of these tumors. Understanding the pathways that regulate proliferation, self-renewal, survival, and differentiation of malignant and normal stem cells may shed light on mechanisms that lead to cancer and suggest better, modes of treatment.

引用

页码：1111 / 1115

页数：5

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