Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication

被引：100

作者：

Allen, TM

Mortara, L

Mothé, BR

Liebl, M

Jing, PC

Calore, B

Piekarczyk, M

Ruddersdorf, R

O'Connor, DH

Wang, X

Wang, CX

Allison, DB

Altman, JD

Sette, A

Desrosiers, RC

Sutter, G

Watkins, DI

机构：

[1] Univ Wisconsin, Wisconsin Reg Primate Res Ctr, Madison, WI 53715 USA

[2] GSF, Inst Mol Virol, D-81675 Munich, Germany

[3] New England Reg Primate Res Ctr, Southborough, MA 01772 USA

[4] Epimmune Inc, San Diego, CA 92121 USA

[5] Univ Alabama, Dept Nutr Sci, Birmingham, AL 35294 USA

[6] Univ Alabama, Clin Nutr Res Ctr, Birmingham, AL 35294 USA

[7] Univ Alabama, Dept Biostat, Sect Stat Genet, Birmingham, AL 35294 USA

[8] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA

[9] Univ Wisconsin, Sch Med, Dept Pathol & Lab Med, Madison, WI 53706 USA

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 08期

关键词：

D O I：

10.1128/JVI.76.8.4108-4112.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role of Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian immunodeficiency virus SIVmac239 replication after using a DNA-prime, vaccinia virus Ankara-boost vaccine regimen. Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls.

引用

页码：4108 / 4112

页数：5

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