DT-13 suppresses MDA-MB-435 cell adhesion and invasion by inhibiting MMP-2/9 via the p38 MAPK pathway

被引：46

作者：

Zhang, Yuanyuan ^{[1
,2
,3
]}

Liu, Jihua ^{[2
]}

Kou, Junping ^{[1
]}

Yu, Jun ^{[3
]}

Yu, Boyang ^{[1
,2
]}

机构：

[1] China Pharmaceut Univ, Dept Complex Prescript TCM, Nanjing 211198, Jiangsu, Peoples R China

[2] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China

[3] Yale Univ, Sch Med, Dept Internal Med, Sect Cardiovasc Med, New Haven, CT 06520 USA

来源：

MOLECULAR MEDICINE REPORTS | 2012年 / 6卷 / 05期

关键词：

DT-13; MDA-MB-435; invasion; p38; matrix metallo-proteinase-9; BREAST-CANCER CELLS; MATRIX METALLOPROTEINASES; TUMOR-METASTASIS; MOLECULAR-MECHANISMS; LIRIOPE-MUSCARI; KAPPA-B; EXPRESSION; ANGIOGENESIS; OVEREXPRESSION; TUBER;

D O I：

10.3892/mmr.2012.1047

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Previous research has shown that the Dwarf lilyturf tuber has antitumor effects. The antitumor ability of DT-13, a saponin monomer isolated from the roots of the Dwarf lilyturf tuber, is discussed in this study. The results showed that DT-13 inhibited the proliferation, adhesion and invasion of MDA-MB-435 cells. DT-13 decreased the excretion and expression of MMP-2/9. Furthermore, DT-13 inhibited the phosphorylation of p38 in MDA-MB-435 cells. In conclusion, the results suggest that DT-13 possesses anticancer and antimetastatic properties by inhibiting the invasion of cancer cells.

引用

页码：1121 / 1125

页数：5

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