Human natural killer cell inhibitory receptors bind to HLA class I molecules

被引：51

作者：

Dohring, C ^{[1
]}

Colonna, M ^{[1
]}

机构：

[1] BASEL INST IMMUNOL,CH-4005 BASEL,SWITZERLAND

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1996年 / 26卷 / 02期

关键词：

natural killer; cytotoxicity; natural killer cell receptor; major histocompatibility complex; HLA-C;

D O I：

10.1002/eji.1830260215

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To obtain direct evidence that human natural killer cell (NK) inhibitory receptors physically interact with polymorphic determinants of major histocompatibility complex class I molecules, a receptor termed NK-associated transcript-2 has been produced as a soluble fusion protein with the human IgG1 Fc portion. This soluble receptor bind specifically to HLA-C alleles with serine 77 and asparagine 80 in cell adhesion assays.

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收藏

页码：365 / 369

页数：5

相关论文

共 17 条

[1] CLONING OF IMMUNOGLOBULIN-SUPERFAMILY MEMBERS ASSOCIATED WITH HLA-C AND HLA-B RECOGNITION BY HUMAN NATURAL-KILLER-CELLS [J].

COLONNA, M ;

SAMARIDIS, J .

SCIENCE, 1995, 268 (5209) :405-408

[2] HLA-C IS THE INHIBITORY LIGAND THAT DETERMINES DOMINANT RESISTANCE TO LYSIS BY NK1-SPECIFIC AND NK2-SPECIFIC NATURAL-KILLER-CELLS [J].

COLONNA, M ;

BORSELLINO, G ;

FALCO, M ;

FERRARA, GB ;

STROMINGER, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (24) :12000-12004

[3]

DANDREA A, 1995, J IMMUNOL, V155, P2306

[4] A NATURAL-KILLER-CELL RECEPTOR-SPECIFIC FOR A MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I MOLECULE [J].

DANIELS, BF ;

KARLHOFER, FM ;

SEAMAN, WE ;

YOKOYAMA, WM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (02) :687-692

[5] LY-49 MEDIATES EL4 LYMPHOMA ADHESION TO ISOLATED CLASS-I MAJOR HISTOCOMPATIBILITY COMPLEX-MOLECULES [J].

KANE, KP .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (03) :1011-1015

[6] NKB1 - A NATURAL-KILLER-CELL RECEPTOR INVOLVED IN THE RECOGNITION OF POLYMORPHIC HLA-B MOLECULES [J].

LITWIN, V ;

GUMPERZ, J ;

PARHAM, P ;

PHILLIPS, JH ;

LANIER, LL .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (02) :537-543

[7]

MELERO I, 1994, J IMMUNOL, V152, P1662

[8] P58 MOLECULES AS PUTATIVE RECEPTORS FOR MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) CLASS-I MOLECULES IN HUMAN NATURAL-KILLER (NK) CELLS - ANTI-P58 ANTIBODIES RECONSTITUTE LYSIS OF MHC CLASS-I-PROTECTED CELLS IN NK CLONES DISPLAYING DIFFERENT SPECIFICITIES [J].

MORETTA, A ;

VITALE, M ;

BOTTINO, C ;

ORENGO, AM ;

MORELLI, L ;

AUGUGLIARO, R ;

BARBARESI, M ;

CICCONE, E ;

MORETTA, L .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (02) :597-604

[9] CD31/PECAM-1 IS A LIGAND FOR ALPHA(V)BETA(3) INTEGRIN INVOLVED IN ADHESION OF LEUKOCYTES TO ENDOTHELIUM [J].

PIALI, L ;

HAMMEL, P ;

UHEREK, C ;

BACHMANN, F ;

GISLER, RH ;

DUNON, D ;

IMHOF, BA .

JOURNAL OF CELL BIOLOGY, 1995, 130 (02) :451-460

[10]

SHIMIZU Y, 1989, J IMMUNOL, V142, P3320