Primary association of a TNF gene polymorphism with susceptibility to multiple sclerosis

被引：74

作者：

Fernandez-Arquero, M

Arroyo, R

Rubio, A

Martin, C

Vigil, P

Conejero, L

Figueredo, MA

de la Concha, EG ^{[1
]}

机构：

[1] Hosp Univ San Carlos, Dept Immunol, Madrid 28040, Spain

[2] Hosp Univ San Carlos, Dept Neurol, Madrid 28040, Spain

来源：

NEUROLOGY | 1999年 / 53卷 / 06期

关键词：

MS; tumor necrosis factor; HLA class II; polymorphism; gene association;

D O I：

10.1212/WNL.53.6.1361

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The associations of three promoter polymorphisms in the tumor necrosis factor (TNFA) gene have been studied in 238 patients and 324 control subjects. A significant correlation was found between MS susceptibility and the TNFA-376 polymorphism. This association was independent of the human leukocyte antigen (HLA) class II association and the combined inheritance of HLA-DRB1*1501 and the TNFA-376A allele more than additively increased susceptibility to MS.

引用

收藏

页码：1361 / 1363

页数：3

相关论文

共 10 条

[1]

Bello N, 1996, REV MAL RESPIR, V13, P37

[2]

Brinkman BMN, 1997, BRIT J RHEUMATOL, V36, P516

[3] Combined effect of HLA-DRB1* 1501 and interleukin-1 receptor antagonist gene allele 2 in susceptibility to relapsing/remitting multiple sclerosis [J].

delaConcha, EG ;

Arroyo, R ;

Crusius, JBA ;

Campillo, JA ;

Martin, C ;

deSeijas, E ;

Pena, AS ;

Claveria, LE ;

FernandezArquero, M .

JOURNAL OF NEUROIMMUNOLOGY, 1997, 80 (1-2) :172-178

[4]

HAUSER SL, 1995, ANN NEUROL, V38, P702

[5] TNF-alpha promoter polymorphisms, production and susceptibility to multiple sclerosis in different groups of patients [J].

Huizinga, TWJ ;

Westendorp, RGJ ;

Bollen, ELEM ;

Keijsers, V ;

Brinkman, BMN ;

Langermans, JAM ;

Breedveld, FC ;

Verweij, CL ;

vandeGaer, L ;

Dams, L ;

Crusius, JBA ;

GarciaGonzalez, A ;

vanOosten, BW ;

Polman, CH ;

Pena, AS .

JOURNAL OF NEUROIMMUNOLOGY, 1997, 72 (02) :149-153

[6]

Marrosu MG, 1997, AM J HUM GENET, V61, P454

[7] Genetic structure of IDDM1: Two separate regions in the major histocompatibility complex contribute to susceptibility or protection [J].

Moghaddam, PH ;

de Knijf, P ;

Roep, BO ;

Van der Auwera, B ;

Naipal, A ;

Gorus, F ;

Schuit, F ;

Giphart, MJ .

DIABETES, 1998, 47 (02) :263-269

[8] Genetic variation in the tumor necrosis factor alpha gene and the outcome of multiple sclerosis [J].

Weinshenker, BG ;

Wingerchuk, DM ;

Liu, Q ;

Bissonet, AS ;

Schaid, DJ ;

Sommer, SS .

NEUROLOGY, 1997, 49 (02) :378-385

[9] Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation [J].

Wilson, AG ;

Symons, JA ;

McDowell, TL ;

McDevitt, HO ;

Duff, GW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (07) :3195-3199

[10] A population-based case-control study of the tumor necrosis factor alpha-308 polymorphism in multiple sclerosis [J].

Wingerchuk, D ;

Liu, Q ;

Sobell, J ;

Sommer, S ;

Weinshenker, BG .

NEUROLOGY, 1997, 49 (02) :626-628