Neuroscience - Long-term potentiation - A decade of progress?

被引：2133

作者：

Malenka, RC ^{[1
]}

Nicoll, RA

机构：

[1] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Nancy Friend Pritzker Lab, Palo Alto, CA 94304 USA

[2] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA

来源：

SCIENCE | 1999年 / 285卷 / 5435期

关键词：

D O I：

10.1126/science.285.5435.1870

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may under learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory.

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页码：1870 / 1874

页数：5

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