Life with 6000 genes

被引：2752

作者：

Goffeau, A

Barrell, BG

Bussey, H

Davis, RW

Dujon, B

Feldmann, H

Galibert, F

Hoheisel, JD

Jacq, C

Johnston, M

Louis, EJ

Mewes, HW

Murakami, Y

Philippsen, P

Tettelin, H

Oliver, SG

机构：

[1] SANGER CTR,HINXTON CB10 1SA,CAMBRIDGE,ENGLAND

[2] MCGILL UNIV,DEPT BIOL,MONTREAL,PQ H3A 1B1,CANADA

[3] STANFORD UNIV,BECKMAN CTR,DEPT BIOCHEM,STANFORD,CA 94305

[4] UNIV PARIS 06,CNRS,URA 1149,UNITE GENET MOL LEVURES,F-75724 PARIS 15,FRANCE

[5] UNIV PARIS 06,UPR927,F-75724 PARIS 15,FRANCE

[6] UNIV MUNICH,INST PHYSIOL CHEM,D-80336 MUNICH,GERMANY

[7] FAC MED,CNRS,UPR 41,LAB BIOCHIM MOL,F-35043 RENNES,FRANCE

[8] DEUTSCH KREBSFORSCHUNGSZENTRUM,D-69120 HEIDELBERG,GERMANY

[9] ECOLE NORMALE SUPER,CNRS,URA 1302,F-75230 PARIS 05,FRANCE

[10] WASHINGTON UNIV,SCH MED,DEPT GENET,ST LOUIS,MO 63110

[11] JOHN RADCLIFFE HOSP,INST MOL MED,OXFORD OX3 9DU,ENGLAND

[12] MAX PLANCK INST BIOCHEM,MARTINSRIED INST PROT STRUCT,D-82152 MARTINSRIED,GERMANY

[13] UNIV BASEL,INST APPL MICROBIOL,BASEL,SWITZERLAND

[14] UNIV MANCHESTER,INST SCI & TECHNOL,DEPT BIOCHEM & APPL MOL BIOL,MANCHESTER M60 1QD,LANCS,ENGLAND

[15] RIKEN,TSUKUBA LIFE SCI CTR,DIV HUMAN GENOME RES,TSUKUBA,IBARAKI 305,JAPAN

来源：

SCIENCE | 1996年 / 274卷 / 5287期

基金：

英国惠康基金;

关键词：

D O I：

10.1126/science.274.5287.546

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The genome of the yeast Saccharomyces cerevisiae has been completely sequenced through a worldwide collaboration. The sequence of 12,068 kilobases defines 5885 potential protein-encoding genes, approximately 140 genes specifying ribosomal RNA, 40 genes for small nuclear RNA molecules, and 275 transfer RNA genes. In addition, the complete sequence provides information about the higher order organization of yeast's 16 chromosomes and allows some insight into their evolutionary history. The genome shows a considerable amount of apparent genetic redundancy, and one of the major problems to be tackled during the next stage of the yeast genome project is to elucidate the biological functions of all of these genes.

引用

页码：546 / &

页数：6

共 82 条

[1] AgTHR4, a new selection marker for transformation of the filamentous fungus Ashbya gossypii, maps in a four-gene cluster that is conserved between A-gossypii and Saccharomyces cerevisiae [J].

AltmannJohl, R ;

Philippsen, P .

MOLECULAR & GENERAL GENETICS, 1996, 250 (01) :69-80

[2]

BARRELL B, UNPUB

[3] Yeast genes and human disease [J].

Bassett, DE ;

Boguski, MS ;

Hieter, P .

NATURE, 1996, 379 (6566) :589-590

[4] A SIMPLE AND EFFICIENT METHOD FOR DIRECT GENE DELETION IN SACCHAROMYCES-CEREVISIAE [J].

BAUDIN, A ;

OZIERKALOGEROPOULOS, O ;

DENOUEL, A ;

LACROUTE, F ;

CULLIN, C .

NUCLEIC ACIDS RESEARCH, 1993, 21 (14) :3329-3330

[5]

BECAM AM, 1995, YEAST, V11, pS300

[6] HET-A, A TRANSPOSABLE ELEMENT SPECIFICALLY INVOLVED IN HEALING BROKEN CHROMOSOME ENDS IN DROSOPHILA-MELANOGASTER [J].

BIESSMANN, H ;

VALGEIRSDOTTIR, K ;

LOFSKY, A ;

CHIN, C ;

GINTHER, B ;

LEVIS, RW ;

PARDUE, ML .

MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (09) :3910-3918

[7] Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii [J].

Bult, CJ ;

White, O ;

Olsen, GJ ;

Zhou, LX ;

Fleischmann, RD ;

Sutton, GG ;

Blake, JA ;

FitzGerald, LM ;

Clayton, RA ;

Gocayne, JD ;

Kerlavage, AR ;

Dougherty, BA ;

Tomb, JF ;

Adams, MD ;

Reich, CI ;

Overbeek, R ;

Kirkness, EF ;

Weinstock, KG ;

Merrick, JM ;

Glodek, A ;

Scott, JL ;

Geoghagen, NSM ;

Weidman, JF ;

Fuhrmann, JL ;

Nguyen, D ;

Utterback, TR ;

Kelley, JM ;

Peterson, JD ;

Sadow, PW ;

Hanna, MC ;

Cotton, MD ;

Roberts, KM ;

Hurst, MA ;

Kaine, BP ;

Borodovsky, M ;

Klenk, HP ;

Fraser, CM ;

Smith, HO ;

Woese, CR ;

Venter, JC .

SCIENCE, 1996, 273 (5278) :1058-1073

[8] THE NUCLEOTIDE-SEQUENCE OF CHROMOSOME-I FROM SACCHAROMYCES-CEREVISIAE [J].

BUSSEY, H ;

KABACK, DB ;

ZHONG, WW ;

VO, DT ;

CLARK, MW ;

FORTIN, N ;

HALL, J ;

OUELLETTE, BFF ;

KENG, T ;

BARTON, AB ;

SU, YP ;

DAVIES, CJ ;

STORMS, RK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (09) :3809-3813

[9]

BUSSEY H, UNPUB

[10]

CARLSON M, 1985, MOL CELL BIOL, V5, P410

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