Xnr4: A Xenopus nodal-related gene expressed in the Spemann organizer

被引：139

作者：

Joseph, EM ^{[1
]}

Melton, DA ^{[1
]}

机构：

[1] HARVARD UNIV,HOWARD HUGHES MED INST,DEPT MOL & CELLULAR BIOL,CAMBRIDGE,MA 02138

来源：

DEVELOPMENTAL BIOLOGY | 1997年 / 184卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1006/dbio.1997.8510

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have isolated a novel TGF beta-like gene from Xenopus which is highly related to mouse nodal. The gene, Xnr4, is expressed at the gastrula stage in the Spemann organizer and at later stages in the notochord and neural tube. Ectopic expression of Xnr4 can induce and dorsalize mesoderm. These studies suggest that Xnr4, along with other nodal-related genes (Xnr1-3), may participate in mesodermal patterning and possibly neural development. (C) 1997 Academic Press.

引用

页码：367 / 372

页数：6

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