共 118 条
Signaling and functions of angiopoietin-1 in vascular protection
被引:411
作者:

Brindle, NPJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Leicester, Dept Cardiovasc Sci, Leicester LE2 7LX, Leics, England

Saharinen, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Leicester, Dept Cardiovasc Sci, Leicester LE2 7LX, Leics, England

Alitalo, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Leicester, Dept Cardiovasc Sci, Leicester LE2 7LX, Leics, England
机构:
[1] Univ Leicester, Dept Cardiovasc Sci, Leicester LE2 7LX, Leics, England
[2] Univ Helsinki, Mol Canc Biol Lab, FIN-00014 Helsinki, Finland
[3] Univ Helsinki, Ludwig Inst Canc Res Biomed Helsinki, FIN-00014 Helsinki, Finland
关键词:
angiopoietin;
endothelial;
Tie1;
Tie2;
integrin;
D O I:
10.1161/01.RES.0000218275.54089.12
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Angiopoietin-1 (Ang1) has powerful vascular protective effects: suppressing plasma leakage, inhibiting vascular inflammation, and preventing endothelial death. Preclinical studies indicate that Ang1 may be therapeutically useful in a number of situations, including treatment of edema, endotoxemia, and transplant arteriosclerosis. However, the ligand has also been implicated in vessel remodeling, induction of angiogenesis and pulmonary hypertension, indicating that strategies to minimize any deleterious effects while optimizing vessel protection are likely to be needed. This review surveys the published data on vascular protective effects of Ang1 and highlights the therapeutic potential of this ligand, as well as possible limitations to its use. We also consider the data on Ang1 receptors and speculate on how to maximize therapeutic benefit by targeting the Tie receptors.
引用
收藏
页码:1014 / 1023
页数:10
相关论文
共 118 条
[1]
Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche
[J].
Arai, F
;
Hirao, A
;
Ohmura, M
;
Sato, H
;
Matsuoka, S
;
Takubo, K
;
Ito, K
;
Koh, GY
;
Suda, T
.
CELL,
2004, 118 (02)
:149-161

Arai, F
论文数: 0 引用数: 0
h-index: 0
机构: Keio Univ, Sch Med, Sakaguchi Lab Dev Biol, Dept Cell Differentiat,Shinjuku Ku, Tokyo 1608582, Japan

Hirao, A
论文数: 0 引用数: 0
h-index: 0
机构: Keio Univ, Sch Med, Sakaguchi Lab Dev Biol, Dept Cell Differentiat,Shinjuku Ku, Tokyo 1608582, Japan

Ohmura, M
论文数: 0 引用数: 0
h-index: 0
机构: Keio Univ, Sch Med, Sakaguchi Lab Dev Biol, Dept Cell Differentiat,Shinjuku Ku, Tokyo 1608582, Japan

Sato, H
论文数: 0 引用数: 0
h-index: 0
机构: Keio Univ, Sch Med, Sakaguchi Lab Dev Biol, Dept Cell Differentiat,Shinjuku Ku, Tokyo 1608582, Japan

Matsuoka, S
论文数: 0 引用数: 0
h-index: 0
机构: Keio Univ, Sch Med, Sakaguchi Lab Dev Biol, Dept Cell Differentiat,Shinjuku Ku, Tokyo 1608582, Japan

Takubo, K
论文数: 0 引用数: 0
h-index: 0
机构: Keio Univ, Sch Med, Sakaguchi Lab Dev Biol, Dept Cell Differentiat,Shinjuku Ku, Tokyo 1608582, Japan

Ito, K
论文数: 0 引用数: 0
h-index: 0
机构: Keio Univ, Sch Med, Sakaguchi Lab Dev Biol, Dept Cell Differentiat,Shinjuku Ku, Tokyo 1608582, Japan

Koh, GY
论文数: 0 引用数: 0
h-index: 0
机构: Keio Univ, Sch Med, Sakaguchi Lab Dev Biol, Dept Cell Differentiat,Shinjuku Ku, Tokyo 1608582, Japan

Suda, T
论文数: 0 引用数: 0
h-index: 0
机构: Keio Univ, Sch Med, Sakaguchi Lab Dev Biol, Dept Cell Differentiat,Shinjuku Ku, Tokyo 1608582, Japan
[2]
Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization
[J].
Asahara, T
;
Chen, DH
;
Takahashi, T
;
Fujikawa, K
;
Kearney, M
;
Magner, M
;
Yancopoulos, GD
;
Isner, JM
.
CIRCULATION RESEARCH,
1998, 83 (03)
:233-240

Asahara, T
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, Sch Med, St Elizabeths Med Ctr, Dept Med Cardiol, Boston, MA 02135 USA

Chen, DH
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, Sch Med, St Elizabeths Med Ctr, Dept Med Cardiol, Boston, MA 02135 USA

Takahashi, T
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, Sch Med, St Elizabeths Med Ctr, Dept Med Cardiol, Boston, MA 02135 USA

Fujikawa, K
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, Sch Med, St Elizabeths Med Ctr, Dept Med Cardiol, Boston, MA 02135 USA

Kearney, M
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, Sch Med, St Elizabeths Med Ctr, Dept Med Cardiol, Boston, MA 02135 USA

Magner, M
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, Sch Med, St Elizabeths Med Ctr, Dept Med Cardiol, Boston, MA 02135 USA

Yancopoulos, GD
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, Sch Med, St Elizabeths Med Ctr, Dept Med Cardiol, Boston, MA 02135 USA

Isner, JM
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, Sch Med, St Elizabeths Med Ctr, Dept Med Cardiol, Boston, MA 02135 USA
[3]
Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells
[J].
Audero, E
;
Cascone, I
;
Maniero, F
;
Napione, L
;
Arese, M
;
Lanfrancone, L
;
Bussolino, F
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2004, 279 (13)
:13224-13233

Audero, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Turin, Sch Med, Inst Canc Res & Treatment, Div Mol Angiogeneis, I-10060 Candiolo, Italy

Cascone, I
论文数: 0 引用数: 0
h-index: 0
机构: Univ Turin, Sch Med, Inst Canc Res & Treatment, Div Mol Angiogeneis, I-10060 Candiolo, Italy

Maniero, F
论文数: 0 引用数: 0
h-index: 0
机构: Univ Turin, Sch Med, Inst Canc Res & Treatment, Div Mol Angiogeneis, I-10060 Candiolo, Italy

论文数: 引用数:
h-index:
机构:

Arese, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Turin, Sch Med, Inst Canc Res & Treatment, Div Mol Angiogeneis, I-10060 Candiolo, Italy

Lanfrancone, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ Turin, Sch Med, Inst Canc Res & Treatment, Div Mol Angiogeneis, I-10060 Candiolo, Italy

Bussolino, F
论文数: 0 引用数: 0
h-index: 0
机构: Univ Turin, Sch Med, Inst Canc Res & Treatment, Div Mol Angiogeneis, I-10060 Candiolo, Italy
[4]
Angiogenic actions of angiopoietin-1 require endothelium-derived nitric oxide
[J].
Babaei, S
;
Teichert-Kuliszewska, K
;
Zhang, QW
;
Jones, N
;
Dumont, DJ
;
Stewart, DJ
.
AMERICAN JOURNAL OF PATHOLOGY,
2003, 162 (06)
:1927-1936

Babaei, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON M5B 1W8, Canada

Teichert-Kuliszewska, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON M5B 1W8, Canada

Zhang, QW
论文数: 0 引用数: 0
h-index: 0
机构: Univ Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON M5B 1W8, Canada

Jones, N
论文数: 0 引用数: 0
h-index: 0
机构: Univ Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON M5B 1W8, Canada

Dumont, DJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON M5B 1W8, Canada

Stewart, DJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON M5B 1W8, Canada
[5]
Age-related changes in vascular endothelial growth factor dependency and angiopoietin-1 - Induced plasticity of adult blood vessels
[J].
Baffert, F
;
Thurston, G
;
Rochon-Duck, M
;
Le, T
;
Brekken, R
;
McDonald, DM
.
CIRCULATION RESEARCH,
2004, 94 (07)
:984-992

Baffert, F
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Anat, Cardiovasc Res Inst, San Francisco, CA 94143 USA

Thurston, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Anat, Cardiovasc Res Inst, San Francisco, CA 94143 USA

Rochon-Duck, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Anat, Cardiovasc Res Inst, San Francisco, CA 94143 USA

Le, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Anat, Cardiovasc Res Inst, San Francisco, CA 94143 USA

Brekken, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Anat, Cardiovasc Res Inst, San Francisco, CA 94143 USA

McDonald, DM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Anat, Cardiovasc Res Inst, San Francisco, CA 94143 USA
[6]
Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition
[J].
Barton, WA
;
Tzvetkova, D
;
Nikolov, DB
.
STRUCTURE,
2005, 13 (05)
:825-832

Barton, WA
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA

Tzvetkova, D
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA

Nikolov, DB
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA
[7]
The tie receptor tyrosine kinase is expressed by human hematopoietic progenitor cells and by a subset of megakaryocytic cells
[J].
Batard, P
;
Sansilvestri, P
;
Scheinecker, C
;
Knapp, W
;
Debili, N
;
Vainchenker, W
;
Buhring, HJ
;
Monier, MN
;
Kukk, E
;
Partanen, J
;
Matikainen, MT
;
Alitalo, R
;
Hatzfeld, J
;
Alitalo, K
.
BLOOD,
1996, 87 (06)
:2212-2220

Batard, P
论文数: 0 引用数: 0
h-index: 0
机构: HELSINKI UNIV, MOL CANC BIOL LAB, HAARTMAN INST, SF-00014 HELSINKI, FINLAND

Sansilvestri, P
论文数: 0 引用数: 0
h-index: 0
机构: HELSINKI UNIV, MOL CANC BIOL LAB, HAARTMAN INST, SF-00014 HELSINKI, FINLAND

Scheinecker, C
论文数: 0 引用数: 0
h-index: 0
机构: HELSINKI UNIV, MOL CANC BIOL LAB, HAARTMAN INST, SF-00014 HELSINKI, FINLAND

Knapp, W
论文数: 0 引用数: 0
h-index: 0
机构: HELSINKI UNIV, MOL CANC BIOL LAB, HAARTMAN INST, SF-00014 HELSINKI, FINLAND

Debili, N
论文数: 0 引用数: 0
h-index: 0
机构: HELSINKI UNIV, MOL CANC BIOL LAB, HAARTMAN INST, SF-00014 HELSINKI, FINLAND

Vainchenker, W
论文数: 0 引用数: 0
h-index: 0
机构: HELSINKI UNIV, MOL CANC BIOL LAB, HAARTMAN INST, SF-00014 HELSINKI, FINLAND

Buhring, HJ
论文数: 0 引用数: 0
h-index: 0
机构: HELSINKI UNIV, MOL CANC BIOL LAB, HAARTMAN INST, SF-00014 HELSINKI, FINLAND

Monier, MN
论文数: 0 引用数: 0
h-index: 0
机构: HELSINKI UNIV, MOL CANC BIOL LAB, HAARTMAN INST, SF-00014 HELSINKI, FINLAND

Kukk, E
论文数: 0 引用数: 0
h-index: 0
机构: HELSINKI UNIV, MOL CANC BIOL LAB, HAARTMAN INST, SF-00014 HELSINKI, FINLAND

Partanen, J
论文数: 0 引用数: 0
h-index: 0
机构: HELSINKI UNIV, MOL CANC BIOL LAB, HAARTMAN INST, SF-00014 HELSINKI, FINLAND

Matikainen, MT
论文数: 0 引用数: 0
h-index: 0
机构: HELSINKI UNIV, MOL CANC BIOL LAB, HAARTMAN INST, SF-00014 HELSINKI, FINLAND

Alitalo, R
论文数: 0 引用数: 0
h-index: 0
机构: HELSINKI UNIV, MOL CANC BIOL LAB, HAARTMAN INST, SF-00014 HELSINKI, FINLAND

Hatzfeld, J
论文数: 0 引用数: 0
h-index: 0
机构: HELSINKI UNIV, MOL CANC BIOL LAB, HAARTMAN INST, SF-00014 HELSINKI, FINLAND

Alitalo, K
论文数: 0 引用数: 0
h-index: 0
机构: HELSINKI UNIV, MOL CANC BIOL LAB, HAARTMAN INST, SF-00014 HELSINKI, FINLAND
[8]
Direct cell adhesion to the angiopoietins mediated by integrins
[J].
Carlson, TR
;
Feng, YZ
;
Maisonpierre, PC
;
Mrksich, M
;
Morla, AO
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2001, 276 (28)
:26516-26525

Carlson, TR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Comm Canc Biol, Chicago, IL 60637 USA

Feng, YZ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Comm Canc Biol, Chicago, IL 60637 USA

Maisonpierre, PC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Comm Canc Biol, Chicago, IL 60637 USA

Mrksich, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Comm Canc Biol, Chicago, IL 60637 USA

Morla, AO
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Comm Canc Biol, Chicago, IL 60637 USA
[9]
Stable interaction between α5β1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1
[J].
Cascone, I
;
Napione, L
;
Maniero, F
;
Serini, G
;
Bussolino, F
.
JOURNAL OF CELL BIOLOGY,
2005, 170 (06)
:993-1004

Cascone, I
论文数: 0 引用数: 0
h-index: 0
机构: Univ Turin, Dept Oncol Sci, I-10060 Candiolo, Italy

论文数: 引用数:
h-index:
机构:

Maniero, F
论文数: 0 引用数: 0
h-index: 0
机构: Univ Turin, Dept Oncol Sci, I-10060 Candiolo, Italy

Serini, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Turin, Dept Oncol Sci, I-10060 Candiolo, Italy

Bussolino, F
论文数: 0 引用数: 0
h-index: 0
机构: Univ Turin, Dept Oncol Sci, I-10060 Candiolo, Italy
[10]
Tie-2-dependent activation of RhoA and Rac1 participates in endothelial cell motility triggered by angiopoietin-1
[J].
Cascone, I
;
Audero, E
;
Giraudo, E
;
Napione, L
;
Maniero, F
;
Philips, MR
;
Collard, JG
;
Serini, G
;
Bussolino, F
.
BLOOD,
2003, 102 (07)
:2482-2490

Cascone, I
论文数: 0 引用数: 0
h-index: 0
机构: Inst Canc Res & Treatment, I-10060 Candiolo, Torino, Italy

Audero, E
论文数: 0 引用数: 0
h-index: 0
机构: Inst Canc Res & Treatment, I-10060 Candiolo, Torino, Italy

Giraudo, E
论文数: 0 引用数: 0
h-index: 0
机构: Inst Canc Res & Treatment, I-10060 Candiolo, Torino, Italy

论文数: 引用数:
h-index:
机构:

Maniero, F
论文数: 0 引用数: 0
h-index: 0
机构: Inst Canc Res & Treatment, I-10060 Candiolo, Torino, Italy

Philips, MR
论文数: 0 引用数: 0
h-index: 0
机构: Inst Canc Res & Treatment, I-10060 Candiolo, Torino, Italy

Collard, JG
论文数: 0 引用数: 0
h-index: 0
机构: Inst Canc Res & Treatment, I-10060 Candiolo, Torino, Italy

Serini, G
论文数: 0 引用数: 0
h-index: 0
机构: Inst Canc Res & Treatment, I-10060 Candiolo, Torino, Italy

Bussolino, F
论文数: 0 引用数: 0
h-index: 0
机构: Inst Canc Res & Treatment, I-10060 Candiolo, Torino, Italy