Neurogenetic correlates of Parkinson's disease: apolipoprotein-E and cytochrome P450 2D6 genetic polymorphism

被引：37

作者：

Bon, MAM

Steur, ENHJ

de Vos, RAI

Vermes, I

机构：

[1] Hosp Grp, Med Spectrum Twente, Dept Clin Chem, NL-7500 KA Enschede, Netherlands

[2] Hosp Grp, Med Spectrum Twente, Dept Neurol, NL-7500 KA Enschede, Netherlands

[3] Reg Lab Pathol, Enschede, Netherlands

来源：

NEUROSCIENCE LETTERS | 1999年 / 266卷 / 02期

关键词：

apolipoprotein-E; cytochrome P450 2D6; genetic polymorphism; morphological confirmed Parkinson's disease; progression of Parkinson's disease;

D O I：

10.1016/S0304-3940(99)00278-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain tissue of 50 patients with morphological confirmed Parkinson's disease (PD), blood samples from 149 patients with clinical parkinsonism and from 96 healthy control subjects were collected. Apolipoprotein-E (apo E) and cytochrome P450 2D6 (CYP2D6) genotyping were performed by PCR followed by restriction fragment analysis. A significantly higher allele frequency of CYP2D6*4 was found in patients with PD (35%) but not with parkinsonism (14.1%) compared to control subjects (19.8%). The combined alleles frequency of CYP2D6*3 + apoE4 was significantly higher not only in the PD group (33.3%) but also in patients with parkinsonism (22.3%) compared to control subjects (1.6%). These results suggest that there is a substantial overlap not only in the clinical manifestation but also in the genetic risk factors between Parkinson's and Alzheimer's diseases. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：149 / 151

页数：3

共 13 条

[1] Apolipoprotein E genotyping in patients with neurodegenerative diseases [J].