Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation

被引：1209

作者：

Lai, EC ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

NATURE GENETICS | 2002年 / 30卷 / 04期

关键词：

D O I：

10.1038/ng865

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Micro RNAs are a large family of noncoding RNAs of 21-22 nucleotides whose functions are generally unknown. Here a large subset of Drosophila micro RNAs is shown to be perfectly complementary to several classes of sequence motif previously demonstrated to mediate negative post-transcriptional regulation. These findings suggest a more general role for micro RNAs in gene regulation through the formation of RNA duplexes.

引用

页码：363 / 364

页数：2

共 15 条

[1] microRNAs: Tiny regulators with great potential [J].

Ambros, V .

CELL, 2001, 107 (07) :823-826

[2] A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation [J].

Ha, I ;

Wightman, B ;

Ruvkun, G .

GENES & DEVELOPMENT, 1996, 10 (23) :3041-3050

[3] Identification of novel genes coding for small expressed RNAs [J].

Lagos-Quintana, M ;

Rauhut, R ;

Lendeckel, W ;

Tuschl, T .

SCIENCE, 2001, 294 (5543) :853-858

[4] Regulation of Drosophila neurogenesis by RNA:RNA duplexes? [J].

Lai, EC ;

Posakony, JW .

CELL, 1998, 93 (07) :1103-1104

[5]

Lai EC, 1997, DEVELOPMENT, V124, P4847

[6]

Lai EC, 2000, DEVELOPMENT, V127, P291

[7]

Lai EC, 1998, DEVELOPMENT, V125, P4077

[8] An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans [J].

Lau, NC ;

Lim, LP ;

Weinstein, EG ;

Bartel, DP .

SCIENCE, 2001, 294 (5543) :858-862

[9] An extensive class of small RNAs in Caenorhabditis elegans [J].

Lee, RC ;

Ambros, V .

SCIENCE, 2001, 294 (5543) :862-864

[10] THE C-ELEGANS HETEROCHRONIC GENE LIN-4 ENCODES SMALL RNAS WITH ANTISENSE COMPLEMENTARITY TO LIN-14 [J].

LEE, RC ;

FEINBAUM, RL ;

AMBROS, V .

CELL, 1993, 75 (05) :843-854

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