Plasmodium, human and Anopheles genomics and malaria

被引：95

作者：

Hoffman, SL

Subramanian, GM

Collins, FH

Venter, JC

机构：

[1] Celera Gen, Rockville, MD 20850 USA

[2] Univ Notre Dame, Notre Dame, IN 46556 USA

来源：

NATURE | 2002年 / 415卷 / 6872期

关键词：

D O I：

10.1038/415702a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Plasmodium spp. parasites that cause malaria are transmitted to humans by Anopheles spp. mosquitoes. Scientists have now amassed a great body of knowledge about the parasite, its mosquito vector and human host. Yet this year there will be 300-500 million new malaria infections and 1-3 million deaths caused by the disease. We believe that integrated analyses of genome sequence, DNA polymorphisms, and messenger RNA and protein expression profiles will lead to greater understanding of the molecular basis of vector-human and host-parasite interactions and provide strategies to build upon these insights to develop interventions to mitigate human morbidity and mortality from malaria.

引用

页码：702 / 709

页数：8

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