c-Myc enhances protein synthesis and cell size during B lymphocyte development

被引:297
作者
Iritani, BM [1 ]
Eisenman, RN [1 ]
机构
[1] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA
关键词
D O I
10.1073/pnas.96.23.13180
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Members of the myc family of nuclear protooncogenes play roles in cell proliferation, differentiation, and apoptosis, Moreover, inappropriate expression of c-myc genes contributes to the development of many types of cancers, including B cell lymphomas in humans. Although Myc proteins have been shown to function as transcription factors, their immediate effects on the cell have not been well defined. Here we have utilized a murine model of lymphomagenesis (E mu-myc mice) to show that constitutive expression of a c-myc transgene under control of the Ig heavy-chain enhancer (E mu) results in an increase in cell size of normal pretransformed B lymphocytes at all stages of B cell development. Furthermore, we show that c-Myc-induced growth occurs independently of cell cycle phase and correlates with an increase in protein synthesis. These results suggest that Myc may normally function by coordinating expression of growth-related genes in response to mitogenic signals. Deregulated c-myc expression may predispose to cancer by enhancing cell growth to levels required for unrestrained cell division.
引用
收藏
页码:13180 / 13185
页数:6
相关论文
共 63 条
[1]   THE C-MYC ONCOGENE DRIVEN BY IMMUNOGLOBULIN ENHANCERS INDUCES LYMPHOID MALIGNANCY IN TRANSGENIC MICE [J].
ADAMS, JM ;
HARRIS, AW ;
PINKERT, CA ;
CORCORAN, LM ;
ALEXANDER, WS ;
CORY, S ;
PALMITER, RD ;
BRINSTER, RL .
NATURE, 1985, 318 (6046) :533-538
[2]   TRANSCRIPTIONAL ACTIVATION BY THE HUMAN C-MYC ONCOPROTEIN IN YEAST REQUIRES INTERACTION WITH MAX [J].
AMATI, B ;
DALTON, S ;
BROOKS, MW ;
LITTLEWOOD, TD ;
EVAN, GI ;
LAND, H .
NATURE, 1992, 359 (6394) :423-426
[3]  
ASKEW DS, 1991, ONCOGENE, V6, P1915
[4]   MYC AND MAX ASSOCIATE INVIVO [J].
BLACKWOOD, EM ;
LUSCHER, B ;
EISENMAN, RN .
GENES & DEVELOPMENT, 1992, 6 (01) :71-80
[5]   MAX - A HELIX-LOOP-HELIX ZIPPER PROTEIN THAT FORMS A SEQUENCE-SPECIFIC DNA-BINDING COMPLEX WITH MYC [J].
BLACKWOOD, EM ;
EISENMAN, RN .
SCIENCE, 1991, 251 (4998) :1211-1217
[6]   CYCLIN D1 TRANSGENE IMPEDES LYMPHOCYTE MATURATION AND COLLABORATES IN LYMPHOMAGENESIS WITH THE MYC GENE [J].
BODRUG, SE ;
WARNER, BJ ;
BATH, ML ;
LINDEMAN, GJ ;
HARRIS, AW ;
ADAMS, JM .
EMBO JOURNAL, 1994, 13 (09) :2124-2130
[7]   CELL-CYCLE CONTROL OF C-MYC BUT NOT C-RAS EXPRESSION IS LOST FOLLOWING CHEMICAL TRANSFORMATION [J].
CAMPISI, J ;
GRAY, HE ;
PARDEE, AB ;
DEAN, M ;
SONENSHEIN, GE .
CELL, 1984, 36 (02) :241-247
[8]  
CORY S, 1986, ADV CANCER RES, V47, P189, DOI 10.1016/S0065-230X(08)60200-6
[9]  
CORY S, 1988, ANNU REV IMMUNOL, V6, P25
[10]  
CRAIG RW, 1993, CELL GROWTH DIFFER, V4, P349