Is methylglyoxal a causative factor for hypertension development?

被引：36

作者：

Wu, LY ^{[1
]}

机构：

[1] Univ Saskatchewan, Dept Pharmacol, Coll Med, Saskatoon, SK S7N 5E5, Canada

来源：

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 2006年 / 84卷 / 01期

关键词：

methylglyoxal; advanced glycation end-products; hypertension;

D O I：

10.1139/Y05-137

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hypertension is a life-threatening disease that is associated with increased cardiovascular risks. Causes and mechanisms for hypertension development remain poorly understood. Methylglyoxal (MG), a highly reactive Molecule, is a metabolite of sugar. Increased circulation and tissue levels of MG have been documented not only in diabetes but also in hypertension. Many recent Studies also link MG-induced vascular damage to the pathogenic process of hypertension. As such, an etiological role of MG in hypertension development is proposed.

引用

页码：129 / 139

页数：11

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