Messenger-RNA-binding proteins and the messages they carry

被引：1179

作者：

Dreyfuss, G ^{[1
]}

Kim, VN

Kataoka, N

机构：

[1] Univ Penn, Sch Med, Howard Hughes Med Inst, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Dept Biochem & Biophys, Philadelphia, PA 19104 USA

[3] Seoul Natl Univ, Sch Biol Sci, Inst Mol Biol & Genet, Seoul, South Korea

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm760

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

From sites of transcription in the nucleus to the outreaches of the cytoplasm, messenger RNAs are associated with RNA-binding proteins. These proteins influence pre-mRNA processing as well as the transport, localization, translation and stability of mRNAs. Recent discoveries have shown that one group of these proteins marks exon-exon junctions and has a role in mRNA export. These proteins communicate crucial information to the translation machinery for the surveillance of nonsense mutations and for mRNA localization and translation.

引用

页码：195 / 205

页数：11

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