Liver regeneration

被引:2715
作者
Michalopoulos, GK
DeFrances, MC
机构
[1] Department of Pathology, University of Pittsburgh, Pittsburgh
关键词
D O I
10.1126/science.276.5309.60
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Liver regeneration after the loss of hepatic tissue is a fundamental parameter of liver response to injury. Recognized as a phenomenon from mythological times, it is now defined as an orchestrated response induced by specific external stimuli and involving sequential changes in gene expression, growth factor production, and morphologic structure. Many growth factors and cytokines, most notably hepatocyte growth factor, epidermal growth factor, transforming growth factor-alpha, interleukin-6, tumor necrosis factor-alpha, insulin, and norepinephrine, appear to play important roles in this process. This review attempts to integrate the findings of the last three decades and looks toward clues as to the nature of the causes that trigger this fascinating organ and cellular response.
引用
收藏
页码:60 / 66
页数:7
相关论文
共 141 条
[1]  
APPASAMY R, 1993, LAB INVEST, V68, P270
[2]   STIMULATION OF IMMATURE MALE RAT-LIVER GROWTH BY PHENOBARBITAL AND 3-METHYLCHOLANTHRENE [J].
AUGENLICHT, LH ;
ARGYRIS, TS .
EXPERIMENTAL AND MOLECULAR PATHOLOGY, 1975, 22 (01) :1-10
[3]  
BEERSTOLZ D, 1997, J CELL PHYSIOL, V170, P57
[4]   UROKINASE AND UROKINASE RECEPTOR - A PARACRINE AUTOCRINE SYSTEM REGULATING CELL-MIGRATION AND INVASIVENESS [J].
BLASI, F .
BIOESSAYS, 1993, 15 (02) :105-111
[5]   Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium [J].
Block, GD ;
Locker, J ;
Bowen, WC ;
Petersen, BE ;
Katyal, S ;
Strom, SC ;
Riley, T ;
Howard, TA ;
Michalopoulos, GK .
JOURNAL OF CELL BIOLOGY, 1996, 132 (06) :1133-1149
[6]   GLYCOLYTIC ISOENZYMES AND GLYCOGEN METABOLISM IN REGENERATING LIVER FROM RATS ON CONTROLLED FEEDING SCHEDULES [J].
BONNEY, RJ ;
HOPKINS, HA ;
WALKER, PR ;
POTTER, VR .
BIOCHEMICAL JOURNAL, 1973, 136 (01) :115-124
[7]   TRANSFORMING GROWTH FACTOR-BETA MESSENGER-RNA INCREASES DURING LIVER-REGENERATION - A POSSIBLE PARACRINE MECHANISM OF GROWTH-REGULATION [J].
BRAUN, L ;
MEAD, JE ;
PANZICA, M ;
MIKUMO, R ;
BELL, GI ;
FAUSTO, N .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (05) :1539-1543
[8]  
CARR BI, 1986, CANCER RES, V46, P2330
[9]   DOWN-REGULATION OF TRANSFORMING GROWTH-FACTOR-BETA RECEPTOR TYPE-I, TYPE-II, AND TYPE-III DURING LIVER-REGENERATION [J].
CHARI, RS ;
PRICE, DT ;
SUE, SR ;
MEYERS, WC ;
JIRTLE, RL .
AMERICAN JOURNAL OF SURGERY, 1995, 169 (01) :126-132
[10]  
CHU RY, 1995, J BIOL CHEM, V270, P29636