Signal transduction from the B cell antigen-receptor

被引:177
作者
Campbell, KS [1 ]
机构
[1] Fox Chase Canc Ctr, Inst Canc Res, Div Basic Sci, Philadelphia, PA 19111 USA
关键词
D O I
10.1016/S0952-7915(99)80042-9
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Ligation of the B cell antigen-receptor triggers an intricate maze of intercalated biochemical events that ultimately affect B cell biological responses; Recent advances have helped to connect many loose ends by identifying key adaptor proteins, such as BLNK/SLP-65, defining crucial roles for phosphatidylinositol-3-kinase and mapping pathways controlling the mitogen-activated protein kinases (ERK, JNK and p38).
引用
收藏
页码:256 / 264
页数:9
相关论文
共 75 条
[1]   Activation of phospholipase C-γ by phosphatidylinositol 3,4,5-trisphosphate [J].
Bae, YS ;
Cantley, LG ;
Chen, CS ;
Kim, SR ;
Kwon, KS ;
Rhee, SG .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (08) :4465-4469
[2]   Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction [J].
Beals, CR ;
Clipstone, NA ;
Ho, SN ;
Crabtree, GR .
GENES & DEVELOPMENT, 1997, 11 (07) :824-834
[3]   INOSITOL TRISPHOSPHATE AND CALCIUM SIGNALING [J].
BERRIDGE, MJ .
NATURE, 1993, 361 (6410) :315-325
[4]   Biochemistry of antigen receptor signaling in mature and developing B lymphocytes [J].
Birkeland, ML ;
Monroe, JG .
CRITICAL REVIEWS IN IMMUNOLOGY, 1997, 17 (3-4) :353-385
[5]   The structural basis of the activation of Ras by Sos [J].
Boriack-Sjodin, PA ;
Margarit, SM ;
Bar-Sagi, D ;
Kuriyan, J .
NATURE, 1998, 394 (6691) :337-343
[6]   Qualitative regulation of B cell antigen receptor signaling by CD19: Selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization [J].
Buhl, AM ;
Pleiman, CM ;
Rickert, RC ;
Cambier, JC .
JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (11) :1897-1910
[7]   Co-receptor and accessory regulation of B-cell antigen receptor signal transduction [J].
Buhl, AM ;
Cambier, JC .
IMMUNOLOGICAL REVIEWS, 1997, 160 :127-138
[8]  
CAMBIER JC, 1995, J IMMUNOL, V155, P3281
[9]   IGM ANTIGEN RECEPTOR COMPLEX CONTAINS PHOSPHOPROTEIN PRODUCTS OF B29 AND MB-1 GENES [J].
CAMPBELL, KS ;
HAGER, EJ ;
FRIEDRICH, RJ ;
CAMBIER, JC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) :3982-3986
[10]   p62(dok): A constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells [J].
Carpino, N ;
Wisniewski, D ;
Strife, A ;
Marshak, D ;
Kobayashi, R ;
Stillman, B ;
Clarkson, B .
CELL, 1997, 88 (02) :197-204