Putting a new twist on actin: ADF/cofilins modulate actin dynamics

被引：323

作者：

Bamburg, JR

McGough, A

Ono, S

机构：

[1] Dept. of Biochem. and Molec. Biology, Colorado State University, Fort Collins

[2] Verna and Marrs McLean Dept. of B., Baylor College of Medicine, Houston

[3] Dept. of Pathology, Emory University School of Medicine, Atlanta

来源：

TRENDS IN CELL BIOLOGY | 1999年 / 9卷 / 09期

关键词：

D O I：

10.1016/S0962-8924(99)01619-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The actin-depolymerizing factor (ADF)/cofilins are a family of essential actin regulatory proteins, ubiquitous among eukaryotes, that enhance the turnover of actin by regulating the rate constants of polymerization and depolymerization at filament ends, changing the twist of the filament and serving actin filaments. Genetic and cell-biological studies have shown that an ADF/cofilin is required to drive the high turnover of the actin cytoskeleton observed in vivo. The activity of ADF/cofilin is regulated by a variety of mechanisms, including specific phosphorylation. This review addresses aspects of ADF/cofilin structure, dynamic, regulation and function.

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收藏

页码：364 / 370

页数：7

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