Tumour-suppressor genes - Killer in search of a motive?

被引：36

作者：

Clurman, B ^{[1
]}

Groudine, M ^{[1
]}

机构：

[1] UNIV WASHINGTON,SCH MED,SEATTLE,WA 98109

来源：

NATURE | 1997年 / 389卷 / 6647期

关键词：

D O I：

10.1038/38116

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The p53 protein is mutated in over 50% of human cancers, and has gained the title 'guardian of the genome' due to its crucial functions in regulating cell growth and death. A hitherto unknown protein, termed p73, has now been discovered and characterized, and it seems to share structural and functional similarity with p53. But more tests need to be done before p73 can be confirmed as a tumour-suppressor gene.

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页码：122 / 123

页数：2

相关论文

共 9 条

[1] ALLELIC LOSS OF CHROMOSOME-1P36 IN NEUROBLASTOMA IS OF PREFERENTIAL MATERNAL ORIGIN AND CORRELATES WITH N-MYC AMPLIFICATION [J].

CARON, H ;

VANSLUIS, P ;

VANHOEVE, M ;

DEKRAKER, J ;

BRAS, J ;

SLATER, R ;

MANNENS, M ;

VOUTE, PA ;

WESTERVELD, A ;

VERSTEEG, R .

NATURE GENETICS, 1993, 4 (02) :187-190

[2] PREFERENTIAL AMPLIFICATION OF THE PATERNAL ALLELE OF THE N-MYC GENE IN HUMAN NEUROBLASTOMAS [J].

CHENG, JM ;

HIEMSTRA, JL ;

SCHNEIDER, SS ;

NAUMOVA, A ;

CHEUNG, NKV ;

COHN, SL ;

DILLER, L ;

SAPIENZA, C ;

BRODEUR, GM .

NATURE GENETICS, 1993, 4 (02) :191-194

[3] DELETIONS OF A DNA-SEQUENCE IN RETINOBLASTOMAS AND MESENCHYMAL TUMORS - ORGANIZATION OF THE SEQUENCE AND ITS ENCODED PROTEIN [J].

FRIEND, SH ;

HOROWITZ, JM ;

GERBER, MR ;

WANG, XF ;

BOGENMANN, E ;

LI, FP ;

WEINBERG, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (24) :9059-9063

[4] Tumour-suppressor genes: evolving definitions in the genomic age [J].

Haber, D ;

Harlow, E .

NATURE GENETICS, 1997, 16 (04) :320-322

[5] p73 is a human p53-related protein that can induce apoptosis [J].

Jost, CA ;

Marin, MC ;

Kaelin, WG .

NATURE, 1997, 389 (6647) :191-194

[6] Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers [J].

Kaghad, M ;

Bonnet, H ;

Yang, A ;

Creancier, L ;

Biscan, JC ;

Valent, A ;

Minty, A ;

Chalon, P ;

Lelias, JM ;

Dumont, X ;

Ferrara, P ;

McKeon, F ;

Caput, D .

CELL, 1997, 90 (04) :809-819

[7] p53: Puzzle and paradigm [J].

Ko, LJ ;

Prives, C .

GENES & DEVELOPMENT, 1996, 10 (09) :1054-1072

[8] p53, the cellular gatekeeper for growth and division [J].

Levine, AJ .

CELL, 1997, 88 (03) :323-331

[9] TUMOR SUPPRESSION - LESSONS IN P16 FROM PHYLUM FALCONIUM [J].

SHEAFF, RJ ;

ROBERTS, JM .

CURRENT BIOLOGY, 1995, 5 (01) :28-31