Quenching fire with fat: phosphatidylinositides as putative regulators of pain

被引：6

作者：

Caterina, MJ ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2001年 / 22卷 / 12期

关键词：

D O I：

10.1016/S0165-6147(00)01862-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A novel mechanism has been proposed by which diverse inflammatory mediators might regulate thermally- or chemically-evoked pain. The constitutive repression of vanilloid receptor activity by phospholipid binding and its reversal by phospholipase C activation could explain how bradykinin, nerve growth factor and other agents augment pain sensation in the context of tissue injury.

引用

页码：602 / 604

页数：3

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