Endocytosis: How dynamin sets vesicles PHree!

被引：16

作者：

Bottomley, MJ

Lo Surdo, P

Driscoll, PC

机构：

[1] European Mol Biol Lab, Struct Biol Programme, D-69117 Heidelberg, Germany

[2] Univ London Univ Coll, Dept Biochem & Mol Biol, London WC1E 6BT, England

[3] Ludwig Inst Canc Res, London W1P 8BT, England

来源：

CURRENT BIOLOGY | 1999年 / 9卷 / 08期

关键词：

D O I：

10.1016/S0960-9822(99)80184-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The dynamin GTPase is required for clathrin-dependent, receptor-mediated endocytosis. Exciting new studies have shown that dynamin's pleckstrin homology domain binds to phosphatidylinositol 4,5-bisphosphate in vivo, thus localising dynamin directly at the plasma membrane and ultimately enabling vesiculation.

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收藏

页码：R301 / R304

页数：4

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