Genetics and genomics in infectious disease susceptibility

被引：39

作者：

Blackwell, JM ^{[1
]}

机构：

[1] Univ Cambridge, Cambridge Inst Med Res, Sch Clin Med, Cambridge CB2 2XY, England

来源：

TRENDS IN MOLECULAR MEDICINE | 2001年 / 7卷 / 11期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S1471-4914(01)02169-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The past decade has witnessed a rapid transition from the first positional cloning of an infectious disease susceptibility gene (Sic11a1, also called Nramp1) in the mouse to genome-wide scans in human multicase families and the identification of potential disease-causing genes by simple inspection of the public human genome databases. Pathogen genome projects have facilitated multilocus sequence typing of pathogen isolates and studies of ecological fitness and virulence patterns in disease-causing isolates. Comparative sequence analysis of pathogen strains and functional genomics studies are now underway, hopefully providing new insight into infectious disease susceptibility.

引用

页码：521 / 526

页数：6

共 47 条

[1]

ALM JS, IN PRESS GENES IMMUN

[2] Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency [J].

Altare, F ;

Durandy, A ;

Lammas, D ;

Emile, JF ;

Lamhamedi, S ;

Le Deist, F ;

Drysdale, P ;

Jouanguy, E ;

Döffinger, R ;

Bernaudin, F ;

Jeppsson, O ;

Gollob, JA ;

Meinl, E ;

Segal, AW ;

Fischer, A ;

Kumararatne, D ;

Casanova, JL .

SCIENCE, 1998, 280 (5368) :1432-1435

[3] Genetic susceptibility to tuberculosis in Africans: A genome-wide scan [J].

Bellamy, R ;

Beyers, N ;

McAdam, KPWJ ;

Ruwende, C ;

Gie, R ;

Samaai, P ;

Bester, D ;

Meyer, M ;

Corrah, T ;

Collin, M ;

Camidge, DR ;

Wilkinson, D ;

Hoal-van Helden, E ;

Whittle, HC ;

Amos, W ;

van Helden, P ;

Hill, AVS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (14) :8005-8009

[4] GENETIC-REGULATION OF LEISHMANIAL AND MYCOBACTERIAL INFECTIONS - THE LSH/ITY/BCG GENE STORY CONTINUES [J].

BLACKWELL, JM ;

BARTON, CH ;

WHITE, JK ;

ROACH, TIA ;

SHAW, MA ;

WHITEHEAD, SH ;

MOCK, BA ;

SEARLE, S ;

WILLIAMS, H ;

BAKER, AM .

IMMUNOLOGY LETTERS, 1994, 43 (1-2) :99-107

[5]

BLACKWELL JM, IN PRESS CELL MICROB

[6] GENETIC-CONTROL OF NATURAL RESISTANCE TO LEISHMANIA-DONOVANI [J].

BRADLEY, DJ .

NATURE, 1974, 250 (5464) :353-353

[7] Transcript analysis of 1003 novel yeast genes using high-throughput northern hybridizations [J].

Brown, AJP ;

Planta, RJ ;

Restuhadi, F ;

Bailey, DA ;

Butler, PR ;

Cadahia, JL ;

Cerdan, ME ;

De Jonge, M ;

Gardner, DCJ ;

Gent, ME ;

Hayes, A ;

Kolen, CPAM ;

Lombardia, LJ ;

Murad, AMA ;

Oliver, RA ;

Sefton, M ;

Thevelein, JM ;

Tournu, H ;

van Delft, YJ ;

Verbart, DJ ;

Winderickx, J ;

Oliver, SG .

EMBO JOURNAL, 2001, 20 (12) :3177-3186

[8] Thalassemia and malaria: New insights into an old problem [J].

Clegg, JB ;

Weatherall, DJ .

PROCEEDINGS OF THE ASSOCIATION OF AMERICAN PHYSICIANS, 1999, 111 (04) :278-282

[9] RETRACTED: A link between virulence and ecological abundance in natural populations of Staphylococcus aureus (Retracted article. See vol 295, pg 971, 2002) [J].

Day, NPJ ;

Moore, CE ;

Enright, MC ;

Berendt, AR ;

Smith, JM ;

Murphy, MF ;

Peacock, SJ ;

Spratt, BG ;

Feil, EJ .

SCIENCE, 2001, 292 (5514) :114-116

[10]

de Jong R, 1998, SCIENCE, V280, P1435

← 1 2 3 4 5 →