Gua Lou Gui Zhi decoction exerts neuroprotective effects on post-stroke spasticity via the modulation of glutamate levels and AMPA receptor expression

被引:58
作者
Huang, Jia [1 ]
Tao, Jing [1 ]
Xue, Xiehua [2 ]
Yang, Shanli [2 ]
Han, Ping [3 ]
Lin, Zhicheng [3 ]
Xu, Wei [4 ]
Lin, Jiumao [5 ]
Peng, Jun [5 ]
Chen, Lidian [1 ]
机构
[1] Fujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou 350108, Fujian, Peoples R China
[2] Fujian Univ Tradit Chinese Med, MOE Key Lab Tradit Chinese Med Osteol & Traumatol, Fuzhou 350108, Fujian, Peoples R China
[3] Fujian Univ Tradit Chinese Med, Fujian Key Lab Exercise Rehabil, Fuzhou 350108, Fujian, Peoples R China
[4] Fujian Univ Tradit Chinese Med, Coll Chinese Mat Med, Fuzhou 350108, Fujian, Peoples R China
[5] Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108, Fujian, Peoples R China
关键词
spasticity; cerebral ischemia; glutamate; alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors; traditional Chinese medicine; Gua Lou Gui Zhi decoction; INTRATHECAL BACLOFEN; UP-REGULATION; STROKE; PREVALENCE; MANAGEMENT; FOREBRAIN; RATS;
D O I
10.3892/ijmm.2013.1262
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Spasticity is one of the most physically debilitating disabilities following stroke and may slow down the potential success of rehabilitation. Glutamate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors have been shown to play a crucial role in spasticity following cerebral ischemia/reperfusion (I/R) injury. Gua Lou Gui Zhi decoction (GLGZD) is a well-known traditional Chinese formula that has long been used clinically in China to treat muscular spasticity following stroke, epilepsy or spinal cord injury. However, the precise mechanisms behind its neuroprotective and anti-spasticity effects remain poorly understood. In the present study, using a rat model of focal cerebral I/R injury, we evaluated the neuroprotective and anti-spasticity effects of GLGZD and investigated the underlying mechanisms. We found that GLGZD improved neurological deficits and reduced infarct volumes in cerebral I/R-injured rats. In addition, GLGZD reduced cerebral ischemic spasticity since it improved the screen test and Hoffman's reflex (H-reflex) scores. It also reduced glutamate levels in the cerebrospinal fluid and altered the expression of the AMPA receptor subunits. Our data demonstrate that GLGZD exerts neuroprotective and anti-spasticity effects in a cerebral ischemia model via the modulation of glutamate levels and AMPA receptor expression.
引用
收藏
页码:841 / 848
页数:8
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