The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils

被引：32

作者：

Candelario-Jalil, E ^{[1
]}

Alvarez, D ^{[1
]}

Castañeda, JM ^{[1
]}

Al-Dalain, SM ^{[1
]}

Martínez-Sánchez, G ^{[1
]}

Merino, N ^{[1
]}

León, OS ^{[1
]}

机构：

[1] Univ Havana, Dept Pharmacol, CIEB, IFAL, Havana 10600, Cuba

来源：

BRAIN RESEARCH | 2002年 / 927卷 / 02期

关键词：

cyclooxygenase-2; cerebral ischemia; neuroprotection; hippocampus; gerbil; DFU;

D O I：

10.1016/S0006-8993(01)03358-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Several studies suggest that cyclooxygenase-2 contributes to the delayed progression of ischemic brain damage. In this study we examined whether the highly selective cyclooxygenase-2 inhibitor DFU reduces neuronal damage when administered several hours after 5 min of transient forebrain ischemia in gerbils. The extent of ischemic injury was assessed behaviorally by measuring the increases in locomotor activity and by histopathological evaluation of the extent of CA1 hippocampal pyramidal cell injury 7 days after ischemia. DFU treatment (10 mg/kg, p.o.) significantly reduced hippocampal neuronal damage even if the treatment is delayed until 12 h after ischemia. These results suggest that selective cyclooxygenase-2 inhibitors may be a valuable therapeutic strategy for ischemic brain injury. (C) 2002 Published by Elsevier Science B.V.

引用

页码：212 / 215

页数：4

共 24 条

[1] LOCOMOTOR-ACTIVITY IN THE ISCHEMIC GERBIL [J].