Fatty acids and insulin resistance

被引：111

作者：

Boden, G

机构：

[1] TEMPLE UNIV, SCH MED, DIV ENDOCRINOL METAB & DIABET, PHILADELPHIA, PA USA

[2] TEMPLE UNIV, SCH MED, GEN CLIN RES CTR, PHILADELPHIA, PA USA

来源：

DIABETES CARE | 1996年 / 19卷 / 04期

关键词：

D O I：

10.2337/diacare.19.4.394

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have demonstrated that physiological elevations in plasma free fatty acid concentrations inhibit insulin-stimulated glucose uptake in a dose-dependent manner in normal control subjects and in patients with NIDDM. Two possible mechanisms were identified. 1) a fat-related inhibition of glucose transport or phosphorylation that appeared after 3-4 h of fat infusion and 2) a decrease in muscle glycogen synthase activity that appeared after 4-6 h of Eat infusion. We conclude that elevations of plasma FFAs caused insulin resistance and hence may play a significant role in the pathogenesis of insulin resistance in obesity and NIDDM.

引用

收藏

页码：394 / 395

页数：2

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