The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment

被引：552

作者：

Ma, Q

Jones, D

Springer, TA ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Ctr Blood Res, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

来源：

IMMUNITY | 1999年 / 10卷 / 04期

关键词：

D O I：

10.1016/S1074-7613(00)80046-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report that the chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within fetal liver and bone marrow microenvironment, in CXCR4-deficient embryos, pro-B cells are present in blood but hardly detectable in liver; myeloid cells are elevated in blood and reduced in liver compared to wild-type embryos. Mice reconstituted with CXCR4-deficient fetal liver cells have reduced donor-derived mature B lymphocytes in blood and lymphoid organs. The numbers of pro-B and pre-B cells are reduced in bone marrow and abnormally high in blood. Granulocytic cells are reduced in bone marrow but elevated and less mature in the blood. B lineage and granulocytic precursors are released into the periphery in absence of CXCR4.

引用

收藏

页码：463 / 471

页数：9

相关论文

共 32 条

[1] The chemokine SDF-1 is a chemoattractant for human CD34(+) hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34(+) progenitors to peripheral blood [J].

Aiuti, A ;

Webb, IJ ;

Bleul, C ;

Springer, T ;

GutierrezRamos, JC .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (01) :111-120

[2] Chemokines and leukocyte traffic [J].

Baggiolini, M .

NATURE, 1998, 392 (6676) :565-568

[3]

Berliner N, 1998, Curr Opin Hematol, V5, P49, DOI 10.1097/00062752-199801000-00009

[4] The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry [J].

Bleul, CC ;

Farzan, M ;

Choe, H ;

Parolin, C ;

ClarkLewis, I ;

Sodroski, J ;

Springer, TA .

NATURE, 1996, 382 (6594) :829-833

[5] B lymphocyte chemotaxis regulated in association with microanatomic localization, differentiation state, and B cell receptor engagement [J].

Bleul, CC ;

Schultze, JL ;

Springer, TA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (05) :753-762

[6] The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes [J].

Bleul, CC ;

Wu, LJ ;

Hoxie, JA ;

Springer, TA ;

Mackay, CR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (05) :1925-1930

[7] A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1) [J].

Bleul, CC ;

Fuhlbrigge, RC ;

Casasnovas, JM ;

Aiuti, A ;

Springer, TA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (03) :1101-1109

[8] Chemokines and the arrest of lymphocytes rolling under flow conditions [J].

Campbell, JJ ;

Hedrick, J ;

Zlotnik, A ;

Siani, MA ;

Thompson, DA ;

Butcher, EC .

SCIENCE, 1998, 279 (5349) :381-384

[9] The chemokine SDF-1, stromal cell-derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4 [J].

DApuzzo, M ;

Rolink, A ;

Loetscher, M ;

Hoxie, JA ;

ClarkLewis, I ;

Melchers, F ;

Baggiolini, M ;

Moser, B .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (07) :1788-1793

[10] Expression of the human immunodeficiency virus type-1 coreceptors CXCR-4 (fusin, LESTR) and CKR-5 in CD34(+) hematopoietic progenitor cells [J].

Deichmann, M ;

Kronenwett, R ;

Haas, R .

BLOOD, 1997, 89 (10) :3522-3528

← 1 2 3 4 →