Characteristics of post-transcriptional gene silencing

被引：50

作者：

Chicas, A ^{[1
]}

Macino, G ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dipartimento Biotecnol Cellulari & Ematol, Sezione Genet Mol, I-00161 Rome, Italy

来源：

EMBO REPORTS | 2001年 / 2卷 / 11期

关键词：

D O I：

10.1093/embo-reports/kve231

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A number of gene silencing phenomena that inactivate genes at the post-transcriptional level have been identified. Due to its potential for studying gene function, post-transcriptional gene silencing (PTGS) has become an intense area of research. In this review we describe the different means of inducing PTGS and discuss the possible biological roles of these artificially induced phenomena. We also discuss other features of PTGS such as the mechanism of mRNA degradation, the nature of the silencing signal and the mechanism of PTGS inhibition by viral proteins.

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收藏

页码：992 / 996

页数：5

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