Three dimensional Monte Carlo code for photon migration through complex heterogeneous media including the adult human head

被引：496

作者：

Boas, DA ^{[1
]}

Culver, JP ^{[1
]}

Stott, JJ ^{[1
]}

Dunn, AK ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, NMR Ctr, Charlestown, MA 02129 USA

来源：

OPTICS EXPRESS | 2002年 / 10卷 / 03期

关键词：

D O I：

10.1364/OE.10.000159

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We describe a novel Monte Carlo code for photon migration through 3D media with spatially varying optical properties. The code is validated against analytic solutions of the photon diffusion equation for semi-infinite homogeneous media. The code is also cross-validated for photon migration through a slab with an absorbing heterogeneity. A demonstration of the utility of the code is provided by showing time-resolved photon migration through a human head. This code, known as 'tMCimg', is available on the web and can serve as a resource for solving the forward problem for complex 3D structural data obtained by MRI or CT. (C) 2002 Optical Society of America.

引用

页码：159 / 170

页数：12

共 42 条

[1] A gradient-based optimisation scheme for optical tomography [J].

Arridge, SR ;

Schweiger, M .

OPTICS EXPRESS, 1998, 2 (06) :213-226

[2] PHOTON-MEASUREMENT DENSITY-FUNCTIONS .2. FINITE-ELEMENT-METHOD CALCULATIONS [J].

ARRIDGE, SR ;

SCHWEIGER, M .

APPLIED OPTICS, 1995, 34 (34) :8026-8037

[3] THE THEORETICAL BASIS FOR THE DETERMINATION OF OPTICAL PATHLENGTHS IN TISSUE - TEMPORAL AND FREQUENCY-ANALYSIS [J].

ARRIDGE, SR ;

COPE, M ;

DELPY, DT .

PHYSICS IN MEDICINE AND BIOLOGY, 1992, 37 (07) :1531-1560

[4] The finite element model for the propagation of light in scattering media: A direct method for domains with nonscattering regions [J].

Arridge, SR ;

Dehghani, H ;

Schweiger, M ;

Okada, E .

MEDICAL PHYSICS, 2000, 27 (01) :252-264

[5] Imaging - Tissue optics [J].

Benaron, DA ;

Cheong, WF ;

Stevenson, DK .

SCIENCE, 1997, 276 (5321) :2002-2003

[6] Noninvasive functional imaging of human brain using light [J].

Benaron, DA ;

Hintz, SR ;

Villringer, A ;

Boas, D ;

Kleinschmidt, A ;

Frahm, J ;

Hirth, C ;

Obrig, H ;

van Houten, JC ;

Kermit, EL ;

Cheong, WF ;

Stevenson, DK .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2000, 20 (03) :469-477

[7] Three-dimensional optical tomography of hemodynamics in the human head [J].

Bluestone, AY ;

Abdoulaev, G ;

Schmitz, CH ;

Barbour, RL ;

Hielscher, AH .

OPTICS EXPRESS, 2001, 9 (06) :272-286

[8] Cortical surface-based analysis - I. Segmentation and surface reconstruction [J].

Dale, AM ;

Fischl, B ;

Sereno, MI .

NEUROIMAGE, 1999, 9 (02) :179-194

[9] A transport-backtransport method for optical tomography [J].

Dorn, O .

INVERSE PROBLEMS, 1998, 14 (05) :1107-1130

[10] Does the photon-diffusion coefficient depend on absorption? [J].

Durduran, T ;

Yodh, AG ;

Chance, B ;

Boas, DA .

JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, 1997, 14 (12) :3358-3365

← 1 2 3 4 5 →