Novel Approaches to Neuroprotection Trials in Acute Ischemic Stroke

被引：69

作者：

Tymianski, Michael ^{[1
,2
,3
]}

机构：

[1] Toronto Western Hosp, Res Inst, Univ Hlth Network, Toronto, ON M5T 2S8, Canada

[2] Univ Toronto, Dept Surg, Toronto, ON, Canada

[3] Univ Toronto, Dept Physiol, Toronto, ON, Canada

来源：

STROKE | 2013年 / 44卷 / 10期

基金：

加拿大健康研究院;

关键词：

acute ischemic stroke; animal studies; clinical trials; human studies; neuroprotectants; reperfusion therapies; TISSUE-PLASMINOGEN ACTIVATOR; EXPLICIT INFORMED-CONSENT; CEREBRAL-ARTERY OCCLUSION; ENDOVASCULAR TREATMENT; THERAPEUTIC WINDOW; INTRAVENOUS THROMBOLYSIS; EARLY REPERFUSION; RANDOMIZED-TRIAL; CLINICAL-TRIAL; BRAIN-INJURY;

D O I：

10.1161/STROKEAHA.113.000731

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

[No abstract available]

引用

收藏

页码：2942 / 2950

页数：9

相关论文

共 71 条

[1] Treatment of ischemic brain damage by perturbing NMDA receptor-PSD-95 protein interactions [J].

Aarts, M ;

Liu, YT ;

Liu, LD ;

Besshoh, S ;

Arundine, M ;

Gurd, JW ;

Wang, YT ;

Salter, MW ;

Tymianski, M .

SCIENCE, 2002, 298 (5594) :846-850

[2] The neuroprotective effect of prostaglandin E2 EP1 receptor inhibition has a wide therapeutic window, is sustained in time and is not sexually dimorphic [J].

Abe, Takato ;

Kunz, Alexander ;

Shimamura, Munehisa ;

Zhou, Ping ;

Anrather, Josef ;

Iadecola, Costantino .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2009, 29 (01) :66-72

[3] Magnetic resonance imaging profiles predict clinical response to early reperfusion: The diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study [J].

Albers, Gregory W. ;

Thijs, Vincent N. ;

Wechsle, Lawrence ;

Kemp, Stephanie ;

Schlaug, Gottfried ;

Skalabrin, Elaine ;

Bammer, Roland ;

Kakuda, Wataru ;

Lansberg, Maarten G. ;

Shuaib, Ashfaq ;

Coplin, William ;

Hamilton, Scott ;

Moseley, Michael ;

Marks, Michael P. .

ANNALS OF NEUROLOGY, 2006, 60 (05) :508-517

[4] The URICO-ICTUS study, a phase 3 study of combined treatment with uric acid and rtPA administered intravenously in acute ischaemic stroke patients within the first 4•5 h of onset of symptoms [J].

Amaro, Sergio ;

Canovas, David ;

Castellanos, Mar ;

Gallego, Jaime ;

Marti-Fabregas, Joan ;

Segura, Tomas ;

Chamorro, Angel .

INTERNATIONAL JOURNAL OF STROKE, 2010, 5 (04) :325-328

[5]

[Anonymous], 1992, Fed Regist, V57, P58942

[6]

[Anonymous], 2007, COCHRANE DATABASE SY

[7] Why are stroke patients excluded from TPA therapy? An analysis of patient eligibility [J].

Barber, PA ;

Zhang, J ;

Demchuk, AM ;

Hill, MD ;

Buchan, AM .

NEUROLOGY, 2001, 56 (08) :1015-1020

[8] A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia [J].

Borsello, T ;

Clarke, PGH ;

Hirt, L ;

Vercelli, A ;

Repici, M ;

Schorderet, DF ;

Bogousslavsky, J ;

Bonny, C .

NATURE MEDICINE, 2003, 9 (09) :1180-1186

[9] Neuroprotection by Freezing Ischemic Penumbra Evolution Without Cerebral Blood Flow Augmentation With a Postsynaptic Density-95 Protein Inhibitor [J].

Bratane, Bernt T. ;

Cui, Hong ;

Cook, Douglas J. ;

Bouley, James ;

Tymianski, Michael ;

Fisher, Marc .

STROKE, 2011, 42 (11) :3265-U547

[10] Granulocyte-Colony Stimulating Factor Delays PWI/DWI Mismatch Evolution and Reduces Final Infarct Volume in Permanent-Suture and Embolic Focal Cerebral Ischemia Models in the Rat [J].

Bratane, Bernt T. ;

Bouley, James ;

Schneider, Armin ;

Bastan, Birgul ;

Henninger, Nils ;

Fisher, Marc .

STROKE, 2009, 40 (09) :3102-3106

← 1 2 3 4 5 6 7 8 →