Tumor regression in cancer patients by very low doses of a T cell-engaging antibody

被引：838

作者：

Bargou, Ralf ^{[2
,3
]}

Leo, Eugen ^{[1
,4
]}

Zugmaier, Gerhard ^{[1
,4
]}

Klinger, Matthias ^{[1
,4
]}

Goebeler, Mariele ^{[2
,3
]}

Knop, Stefan ^{[3
]}

Noppeney, Richard ^{[5
]}

Viardot, Andreas ^{[6
]}

Hess, Georg ^{[7
]}

Schuler, Martin ^{[8
]}

Einsele, Hermann ^{[3
]}

Brandl, Christian ^{[1
,4
]}

Wolf, Andreas ^{[1
,4
]}

Kirchinger, Petra ^{[1
,4
]}

Klappers, Petra ^{[1
,4
]}

Schmidt, Margit ^{[1
,4
]}

Riethmueller, Gert ^{[9
]}

Reinhardt, Carsten ^{[1
,4
]}

Baeuerle, Patrick A. ^{[1
,4
]}

Kufer, Peter ^{[1
,4
]}

机构：

[1] Micromet AG, D-81477 Munich, Germany

[2] Univ Wurzburg, Interdisciplinary Phase 1 2 Unit, D-97070 Wurzburg, Germany

[3] Univ Klinikum Wurzburg, Med Klin & Poliklin 2, D-97070 Wurzburg, Germany

[4] Micromet Inc, Bethesda, MD 20817 USA

[5] Univ Klinikum Essen, Klin Hamatol, Med Klin & Poliklin, D-45147 Essen, Germany

[6] Univ Ulm Klinikum, D-89081 Ulm, Germany

[7] Univ Mainz Klinikum, Med Klin & Poliklin 3, D-55131 Mainz, Germany

[8] Univ Klinikum Essen, Innere Tumorforsch Klin, D-45122 Essen, Germany

[9] Univ Munich, Inst Immunol, D-81333 Munich, Germany

来源：

SCIENCE | 2008年 / 321卷 / 5891期

关键词：

D O I：

10.1126/science.1158545

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Previous attempts have shown the potential of T cells in immunotherapy of cancer. Here, we report on the clinical activity of a bispecific antibody construct called blinatumomab, which has the potential to engage all cytotoxic T cells in patients for lysis of cancer cells. Doses as low as 0.005 milligrams per square meter per day in non- Hodgkin's lymphoma patients led to an elimination of target cells in blood. Partial and complete tumor regressions were first observed at a dose level of 0.015 milligrams, and all seven patients treated at a dose level of 0.06 milligrams experienced a tumor regression. Blinatumomab also led to clearance of tumor cells from bone marrow and liver. T cell- engaging antibodies appear to have therapeutic potential for the treatment of malignant diseases.

引用

页码：974 / 977

页数：4

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