Centrally administered orexin/hypocretin activates HPA axis in rats

被引：241

作者：

Kuru, M

Ueta, Y

Serino, R

Nakazato, M

Yamamoto, Y

Shibuya, I

Yamashita, H

机构：

[1] Univ Occupat & Environm Hlth, Sch Med, Dept Physiol, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan

[2] Miyazaki Med Coll, Dept Internal Med 3, Miyazaki 8891692, Japan

来源：

NEUROREPORT | 2000年 / 11卷 / 09期

关键词：

ACTH; corticosterone; hypocretin; orexin; paraventricular nucleus; stress;

D O I：

10.1097/00001756-200006260-00034

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of i.c.v. administration of orexin/hypocretin on plasma ACTH, corticosterone and c-fos mRNA in the paraventricular nucleus (PVN) of the rat were examined. Plasma ACTH levels were markedly increased at 30 min after i.c.v. administration of orexin-A Plasma corticosterone fevers were significantly increased in a dose-related manner 30 min after i.c.v. administration of orexin-A and orexin-B. In situ hybridization histochemistry revealed that the induction of the c-fos mRNA in the parvocellular division of the PVN was increased in a dose-related manner 30 min after i.c.v. administration of orexin-A and orexin-B. These results suggest that central orexin/hypocretin activates hypothalamo-pituitary-adrenal (HPA) axis and may be involved in stress-induced activation of the HPA axis. NeuroReport 11:1977-1980 (C) 2000 Lippincott Williams & Wilkins.

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页码：1977 / 1980

页数：4

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