Natural killer cell receptors

被引：73

作者：

Long, EO

Wagtmann, N

机构：

[1] Laboratory of Immunogenetics, Natl. Inst. Allerg. Infect. Dis., N., Rockville

来源：

CURRENT OPINION IN IMMUNOLOGY | 1997年 / 9卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(97)80080-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The specificity in the recognition of hematopoietic target cells by natural killer cells is primarily provided by inhibitory receptors and several such receptors have been identified in the past year. Surprisingly, the recognition of MHC class I molecules by inhibitory receptors on human natural killer cells involves two different types of receptors, one with Ig domains (killer cell inhibitory receptor), and another with C-type lectin domains (CD94-NKG2). Mouse natural killer cells recognize MHC class I molecules through the C-type lectin Ly49 receptors but also express a receptor, of unknown ligand specificity, that is related to the killer cell inhibitory receptor.

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页码：344 / 350

页数：7

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