Submillisecond kinetics of protein folding

被引：186

作者：

Eaton, WA

Munoz, V

Thompson, PA

Chan, CK

Hofrichter, J

机构：

[1] Laboratory of Chemical Physics, Bldg. 5, Natl. Institutes D., Bethesda

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1997年 / 7卷 / 01期

关键词：

D O I：

10.1016/S0959-440X(97)80003-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New experimental methods permit observation of protein folding and unfolding on the previously inaccessible nanosecond-microsecond timescale. These studies are beginning to establish times for the elementary motions in protein folding - secondary structure and loop formation, local hydrophobic collapse, and global collapse to the compact denatured state. They permit an estimate of about one microsecond for the shortest time in which a protein can possibly fold.

引用

页码：10 / 14

页数：5

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