Myocyte renewal and ventricular remodelling

被引:334
作者
Anversa, P [1 ]
Nadal-Ginard, B [1 ]
机构
[1] New York Med Coll, Dept Med, Cardiovasc Res Inst, Valhalla, NY 10595 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/415240a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Remaining young at heart is a desirable but elusive goal. Unbeknown to us, however, myocyte regeneration may accomplish just that. Continuous cell renewal in the adult myocardium was thought to be impossible, but multipotent cardiac stem cells may be able to renew the myocardium and, under certain circumstances, can be coaxed to repair the broken heart after infarction.
引用
收藏
页码:240 / 243
页数:4
相关论文
共 46 条
[1]   Ventricular myocytes are not terminally differentiated in the adult mammalian heart [J].
Anversa, P ;
Kajstura, J .
CIRCULATION RESEARCH, 1998, 83 (01) :1-14
[2]  
ANVERSA P, 2001, HDB PHYSL 2, V1, P75
[3]  
Bakos É, 2000, J CELL SCI, V113, P4451
[4]   Evidence that human cardiac myocytes divide after myocardial infarction (Publication with Expression of Concern. See vol. 379, pg. 1870, 2018) [J].
Beltrami, AP ;
Urbanek, K ;
Kajstura, J ;
Yan, SM ;
Finato, N ;
Bussani, R ;
Nadal-Ginard, B ;
Silvestri, F ;
Leri, A ;
Beltrami, CA ;
Anversa, P .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (23) :1750-1757
[5]  
Bunting Kevin D., 2000, Blood, V96, P902
[6]   Isolation of endothelial cells from brain, lung, and kidney:: Expression of the multidrug resistance P-glycoprotein isoforms [J].
Demeule, M ;
Labelle, M ;
Régina, A ;
Berthelet, F ;
Béliveau, R .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 281 (03) :827-834
[7]   A monoclonal antibody against the 66-kDa protein expressed in mouse spleen and thymus inhibits Ly-6A.2-dependent cell-cell adhesion [J].
English, A ;
Kosoy, R ;
Pawlinski, R ;
Bamezai, A .
JOURNAL OF IMMUNOLOGY, 2000, 165 (07) :3763-3771
[8]  
Geick A, 2001, J Biol Chem, V276, P14581
[9]   Telomerase activity, cell proliferation, and cancer [J].
Greider, CW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (01) :90-92
[10]  
Hara E, 1996, MOL CELL BIOL, V16, P859