Protective genes expressed in endothelial cells: a regulatory response to injury

被引：169

作者：

Bach, FH ^{[1
]}

Hancock, WW ^{[1
]}

Ferran, C ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,BETH ISRAEL DEACONESS MED CTR,DEPT PATHOL,BOSTON,MA 02215

来源：

IMMUNOLOGY TODAY | 1997年 / 18卷 / 10期

关键词：

D O I：

10.1016/S0167-5699(97)01129-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Endothelial cells (ECs) have evolved to guard against insults that incite inflammation. Response to injury is an active process that, if uncontrolled, can progress to EC death (apoptosis). Here Fritz Bach and colleagues suggest that ECs have a balancing component to their proinflammatory response: they upregulate a set of protective genes, including anti-apoptotic genes, that serve to limit the activation process and thereby regulate the response to injury.

引用

页码：483 / 486

页数：4

共 30 条

[1] Inhibition of bovine endothelial cell activation in vitro by regulated expression of a transdominant inhibitor of NF-kappa B [J].

Anrather, J ;

Csizmadia, V ;

Brostjan, C ;

Soares, MP ;

Bach, FH ;

Winkler, H .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (04) :763-772

[2]

BACH FH, 1994, TRANSPLANT P, V26, P1167

[3] Accommodation of vascularized xenografts: Expression of ''protective genes'' by donor endothelial cells in a host Th2 cytokine environment [J].

Bach, FH ;

Ferran, C ;

Hechenleitner, P ;

Mark, W ;

Koyamada, N ;

Miyatake, T ;

Winkler, H ;

Badrichani, A ;

Candinas, D ;

Hancock, WW .

NATURE MEDICINE, 1997, 3 (02) :196-204

[4] BARRIERS TO XENOTRANSPLANTATION [J].

BACH, FH ;

ROBSON, SC ;

WINKLER, H ;

FERRAN, C ;

STUHLMEIER, KM ;

WRIGHTON, CJ ;

HANCOCK, WW .

NATURE MEDICINE, 1995, 1 (09) :869-873

[5] Accommodation of xenografts: Expression of ''protective genes'' in endothelial and smooth muscle cells [J].

Bach, FH ;

Ferran, C ;

Candinas, D ;

Miyatake, T ;

Koyamada, N ;

Mark, W ;

Hechenleitner, P ;

Hancock, WW .

TRANSPLANTATION PROCEEDINGS, 1997, 29 (1-2) :56-58

[6] An essential role for NF-kappa B in preventing TNF-alpha-induced cell death [J].

Beg, AA ;

Baltimore, D .

SCIENCE, 1996, 274 (5288) :782-784

[7] ACTIVATION OF INTRAGRAFT ENDOTHELIAL AND MONONUCLEAR-CELLS DURING DISCORDANT XENOGRAFT REJECTION [J].

BLAKELY, ML ;

VANDERWERF, WJ ;

BERNDT, MC ;

DALMASSO, AP ;

BACH, FH ;

HANCOCK, WW .

TRANSPLANTATION, 1994, 58 (10) :1059-1066

[8] BCL-X, A BCL-2-RELATED GENE THAT FUNCTIONS AS A DOMINANT REGULATOR OF APOPTOTIC CELL-DEATH [J].

BOISE, LH ;

GONZALEZGARCIA, M ;

POSTEMA, CE ;

DING, LY ;

LINDSTEN, T ;

TURKA, LA ;

MAO, XH ;

NUNEZ, G ;

THOMPSON, CB .

CELL, 1993, 74 (04) :597-608

[9] TRANSCRIPTIONAL REGULATION OF ENDOTHELIAL-CELL ADHESION MOLECULES - NF-KAPPA-B AND CYTOKINE-INDUCIBLE ENHANCERS [J].

COLLINS, T ;

READ, MA ;

NEISH, AS ;

WHITLEY, MZ ;

THANOS, D ;

MANIATIS, T .

FASEB JOURNAL, 1995, 9 (10) :899-909

[10] A20 blocks endothelial cell activation through a NF-kappa B-dependent mechanism [J].

Cooper, JT ;

Stroka, DM ;

Brostjan, C ;

Palmetshofer, A ;

Bach, FH ;

Ferran, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (30) :18068-18073

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