RNA editing and hypermutation by adenosine deamination

被引：171

作者：

Bass, BL

机构：

[1] Department of Biochemistry, Howard Hughes Medical Institute, University of Utah, Salt Lake City

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 05期

关键词：

D O I：

10.1016/S0968-0004(97)01035-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Double-stranded RNA adenosine deaminase (dsRAD) was discovered ten years ago(1,2). In the intervening decade, research on dsRAD has progressed not only predictably, such as with the purification of the enzyme and identification of cDNAs, but also in some quite surprising ways. This review covers both areas of progress, but will concentrate on the surprises, which include the discovery that dsRAD is a member of a larger family of deaminases and the identification of RNAs that appear to be targets for these deaminases in vivo.

引用

收藏

页码：157 / 162

页数：6

相关论文

共 54 条

[1] SYNTHETIC POLYNUCLEOTIDES AND AMINO ACID CODE .5. [J].

BASILIO, C ;

WAHBA, AJ ;

OCHOA, S ;

SPEYER, JF ;

LENGYEL, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1962, 48 (04) :613-&

[2] RNA EDITING - AN I FOR EDITING [J].

BASS, BL .

CURRENT BIOLOGY, 1995, 5 (06) :598-600

[3] AN UNWINDING ACTIVITY THAT COVALENTLY MODIFIES ITS DOUBLE-STRANDED-RNA SUBSTRATE [J].

BASS, BL ;

WEINTRAUB, H .

CELL, 1988, 55 (06) :1089-1098

[4] A DEVELOPMENTALLY REGULATED ACTIVITY THAT UNWINDS RNA DUPLEXES [J].

BASS, BL ;

WEINTRAUB, H .

CELL, 1987, 48 (04) :607-613

[5] BIASED HYPERMUTATION OF VIRAL-RNA GENOMES COULD BE DUE TO UNWINDING MODIFICATION OF DOUBLE-STRANDED-RNA [J].

BASS, BL ;

WEINTRAUB, H ;

CATTANEO, R ;

BILLETER, MA .

CELL, 1989, 56 (03) :331-331

[6] GENERATION AND PROPERTIES OF MEASLES-VIRUS MUTATIONS TYPICALLY ASSOCIATED WITH SUBACUTE SCLEROSING PANENCEPHALITIS [J].

BILLETER, MA ;

CATTANEO, R ;

SPIELHOFER, P ;

KAELIN, K ;

HUBER, M ;

SCHMID, A ;

BACZKO, K ;

TERMEULEN, V .

SLOW INFECTIONS OF THE CENTRAL NERVOUS SYSTEM: THE LEGACY OF DR BJORN SIGURDSSON, 1994, 724 :367-377

[7] EARLY-ONSET EPILEPSY AND POSTNATAL LETHALITY ASSOCIATED WITH AN EDITING-DEFICIENT GLUR-B ALLELE IN MICE [J].

BRUSA, R ;

ZIMMERMANN, F ;

KOH, DS ;

FELDMEYER, D ;

GASS, P ;

SEEBURG, PH ;

SPRENGEL, R .

SCIENCE, 1995, 270 (5242) :1677-1680

[8]

BURNS CM, IN PRESS NATURE

[9] HEPATITIS-D VIRUS-RNA EDITING - SPECIFIC MODIFICATION OF ADENOSINE IN THE ANTIGENOMIC RNA [J].

CASEY, JL ;

GERIN, JL .

JOURNAL OF VIROLOGY, 1995, 69 (12) :7593-7600

[10] STRUCTURAL REQUIREMENTS FOR RNA EDITING IN HEPATITIS-DELTA VIRUS - EVIDENCE FOR A URIDINE-TO-CYTIDINE EDITING MECHANISM [J].

CASEY, JL ;

BERGMANN, KF ;

BROWN, TL ;

GERIN, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (15) :7149-7153

← 1 2 3 4 5 6 →