A comprehensive genetic map of the mouse genome

被引：727

作者：

Dietrich, WF

Miller, J

Steen, R

Merchant, MA

DamronBoles, D

Husain, Z

Dredge, R

Daly, MJ

Ingalls, KA

OConnor, TJ

Evans, CA

DeAngelis, MM

Levinson, DM

Kruglyak, L

Goodman, N

Copeland, NG

Jenkins, NA

Hawkins, TL

Stein, L

Page, DC

Lander, ES

机构：

[1] WHITEHEAD INST BIOMED RES, WHITEHEAD MIT CTR GENOME RES, CAMBRIDGE, MA 02142 USA

[2] NCI, FREDERICK CANC RES & DEV CTR, ABL BASIC RES PROGRAM, MAMMALIAN GENET LAB, FREDERICK, MD 21702 USA

[3] MIT, DEPT BIOL, CAMBRIDGE, MA 02139 USA

[4] MIT, HOWARD HUGHES MED INST, CAMBRIDGE, MA 02139 USA

来源：

NATURE | 1996年 / 380卷 / 6570期

关键词：

D O I：

10.1038/380149a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The availability of dense genetic linkage maps of mammalian genomes makes feasible a wide range of studies, including positional cloning of monogenic traits, genetic dissection of polygenic traits, construction of genome-wide physical maps, rapid marker-assisted construction of congenic strains, and evolutionary comparisons(1,2). We have been engaged for the past five years in a concerted effort to produce a dense genetic map of the laboratory mouse(3-6). Here we present the final report of this project. The map contains 7,377 genetic markers, consisting of 6,580 highly informative simple sequence length polymorphisms integrated with 797 restriction fragment length polymorphisms in mouse genes. The average spacing between markers is about 0.2 centimorgans or 400 kilobases.

引用

页码：149 / 152

页数：4

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