Tripping the switch fantastic: How a protein kinase cascade can convert graded inputs into switch-like outputs

被引：462

作者：

Ferrell, JE

机构：

[1] Department of Molecular Pharmacology, Stanford University, School of Medicine, Stanford

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1996年 / 21卷 / 12期

关键词：

D O I：

10.1016/S0968-0004(96)20026-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent experimental work has shown that the mitogen-activated protein (MAP) kinase cascade can convert graded inputs into switch-like outputs. The cascade could therefore filter out noise (signals of insufficient magnitude or duration) and still respond decisively to supra-threshold stimuli. Here, we explore the biochemical mechanisms likely to be at the root of this behavior.

引用

页码：460 / 466

页数：7

共 32 条

[1]

Bardwell L, 1996, MOL CELL BIOL, V16, P3637

[2]

BLUMER KJ, 1988, J BIOL CHEM, V263, P10836

[3] DIVERSITY IN FUNCTION AND REGULATION OF MAP KINASE PATHWAYS [J].