A proposed mechanism of ALS fails the test in vivo

被引：8

作者：

Orr, HT

机构：

[1] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Inst Human Genet, Minneapolis, MN 55455 USA

来源：

NATURE NEUROSCIENCE | 2002年 / 5卷 / 04期

关键词：

D O I：

10.1038/nn0402-287

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In contrast to prevailing hypotheses, a genetic study shows that the toxic gain of function associated with mutant superoxide dismutase in familial amyotropic lateral sclerosis is unlikely to be due to changes in its oxidative activity causing an increase in free radicals.

引用

页码：287 / 288

页数：2

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